兰州大学机构库 >学院待认领
腹腔热灌注化疗治疗卵巢癌有效性和安全性的系统评价
Alternative TitleEffectiveness and Safety of Intraperitoneal Hyperthermic Perfusion Chemotherapy for ovarian cancer: A systematic Review
柴成梁
Thesis Advisor王晓慧
2015-05-21
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword卵巢癌 腹腔热灌注化疗 系统评价 Meta分析 随机对照试验
Abstract目的 系统评价腹腔热灌注化疗(intraperitoneal hyperthermic perfusion chemotherapy,IHPC)治疗卵巢癌的疗效和安全性,为临床研究和应用提供参考。 方法 计算机检索Embase、Cochrane Library、Web of Science、Pubmed和数字化期刊全文数据库、中国生物医学文献数据库、中文科技期刊数据库以及中国期刊全文数据库,检索时间从建库截止2013 年6月,手工检索中华妇产科杂志、中国实用妇科和产科杂志、Archives of Gynecology and Obstetrics等国内外刊物,并用Google等搜索引擎在互联网上查找相关文献。收集所有比较卵巢癌IHPC联合全身静脉化疗(intravenous chemotherapy,IC)与单纯静脉全身化疗(IC)的随机对照试验(RCT)。由两名参与者严格参照Cochrane Handbook5.0.1质量评价标准独立对纳入文献进行质量评价后,使用RevMan 5.1 软件进行Meta 分析。 结果 全文共纳入10个临床随机对照试验(RCT),723例患者,Meta分析结果显示:IHPC联合IC组与IC组比较,两组的临床有效率、临床受益率、复发转移率及总生存率差异均有统计学意义,其OR(95CI) 分别为4.02(2.85,5.68)、3.14(2.13,5.45)、029(0.20,0.42)及3.30(1.82,5.99)。在安全性上来说,血红蛋白减少、两组在骨髓抑制和恶心呕吐方面的发生率差异无统计学意义。而腹水控制率[OR=4.46,95%CI(1.98,10.02),P=0.0003]差异有统计学意义。 结论 与单纯IC疗法相比,卵巢癌采用IHPC+IC双途径疗法可提高患者的临床有效率、收益率和总生存率,降低患者的复发转移率,并且安全性可以接受,推荐根据患者具体临床情况合理应用。 关键词 卵巢癌;腹腔热灌注化疗;系统评价;Meta分析;随机对照试验
Other AbstractObjective To evaluate the effectineness and safety of intraperitoneal hyperthermic perfusion chemotherapy(IHPC) for ovrian cancer, so as to provide references for clinical practice and study. Methods The following datebases including the Embase, Cochrane Library, Web of Science, Pubmed, WangFang, CBM, VIP and CNKI were searched on computer, from the data of their estabishment to June 2013, relevant journals such as Chinses Journal of Obstetrics Gynecology, Chinses Journal of Practical Gynecology and Obstetrics and Archives of Gynecology and Obstetrics were handsearched, meanwhile we search for relevant literatures with Google and other search engines on the Internet. To collect all relevant randomized controlled trials (RCTs) on IHPC versus intravenous chemotherapy alone(IC)for ovarian cancer. After two researchers independently according to the Cochrane Handbook 5.0.1 quality evaluation standard to evaluate the inclusion literatures. and Meta-analysis was conducted by using RevMan 5.1 software. Rescults A total of 10 RCTs involving 723 patients were included. The results of meta-analyses showed that there were significant difrences between the IHPC group and IC group in clinical efficient, clinical benefit response, recurrence and metastasis rate, overall survival and ascities control rate; the OR value and 95%CI were 4.02 (2.85,5.68), 3.14 (2.13,5.45), 029(0.20,0.42), 3.30 (1.82,5.99) and 4.46(1.98,10.02) respectively; between the two groups there were no significant differences in bone marrow suppression, hemoglobin decreased, nausea and vomiting. Conclusion Compared with IC, IHPC+IC can improve clinical efficient, clinical benefit response and overall survival and reduce recurrence and metastasis rate; additionally, it is safe and feasible, so it is recommended that the specifical condition of patients should be taken into consideration when the therapy is applied to clinic. Key words Ovarian cancer, Intraperitoneal hyperthermic perfusion chemotherapy, Systematic review, Meta-analysis, Randomized controlled trail
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223541
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
柴成梁. 腹腔热灌注化疗治疗卵巢癌有效性和安全性的系统评价[D]. 兰州. 兰州大学,2015.
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