| 分子靶向治疗在头颈部鳞癌的临床应用进展 | |
| Alternative Title | Molecular Targeted Therapy in Advanced Head and Neck Cancer |
| 周霞东 | |
| Thesis Advisor | 关泉林 |
| 2010-05-28 | |
| Degree Grantor | 兰州大学 |
| Place of Conferral | 兰州 |
| Degree Name | 硕士 |
| Keyword | 头颈部癌 分子靶向治疗 临床进展 |
| Abstract | 分子靶向治疗为头颈部鳞癌（SCCHN)的治疗提供了新的手段，它能够特异性的作用于肿瘤发生、发展中起关键作用的靶分子及其调控的信号转导通路，从而达到治疗肿瘤的目的。在SCCHN分子靶向治疗的临床试验中，靶向表皮生长因子受体（EGFR）、血管内皮细胞生长因子（VEGF）和多靶点抑制剂的药物治疗已经显示出了潜在的疗效和良好的发展前景。 |
| Other Abstract | New approaches targeting molecular abnormalities specific to squamous cell carcinoma of the head and neck (SCCHN) has offered a new method to improve patient outcome. The increasing knowledge in the molecular pathogenesis of SCCHN as well as the introduction of molecular targeted therapies in oncology has created an encouraging trend in the management of this malignancy. Early studies of targeted therapies for SCCHN, including targeting the EGFR pathway and inhibiting angiogenesis and multikinase inhibitors, have shown effective and great perspective. This review summarizes the basic knowledge of those key aspects of the molecular pathogenesis. Relevant preclinical and clinical information on novel compounds for SCCHN are also reviewed. |
| URL | 查看原文 |
| Language | 中文 |
| Document Type | 学位论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/223568 |
| Collection | 学院待认领 |
| Affiliation | 临床医学院 |
| Recommended Citation GB/T 7714 | 周霞东. 分子靶向治疗在头颈部鳞癌的临床应用进展[D]. 兰州. 兰州大学,2010. |
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