|Alternative Title||Levels and Clinical Significance of VEGF-D and VEGFR-2 of the Serum in Lung Cancer
|Place of Conferral||兰州
|Other Abstract||Objective:To detect the serum vascular endothelial growth factor D (VEGF-D),vascular endothelial growth factor receptor 2 (VEGFR-2) levels of lung cancer patients;explore the relationship between VEGF-D and VEGFR-2 expression in lung cancer clinical and pathological features and its clinical significance.
Methods:VEGF-D and VEGFR-2 expression of serum in 52 cases of lung cancer and 36 cases of the healthy control group is detected by ELISA.
1.Comparison of lung cancer and control groups, the VEGF-D,VEGFR-2 levels of small cell lung cancer,non-small cell lung cancer patients and healthy controls derives by the rank-sum test P<0.05,the difference is statistically significant.
2.Comparison group of lung cancer patients in accordance with the degree of tumor differentiation,three groups of serum VEGF-D and VEGFR-2 compares by rank sum test, P<0.05, VEGF-D and VEGFR-2 concentration of well differentiated ,moderately differentiated and poorly differentiated are statistically significant.
3.In accordance with the clinical staging of lung cancer group is compared,P<0.05, difference in serum VEGF-D and VEGFR-2 of two groups are statistically significant.
4.According to the TNM stage lung cancer group is compared in two groups of patients with serum VEGF-D and VEGFR-2,P<0.05,according to the TNM stage grouping serum VEGF-D and VEGFR-2 difference is statistically significant.
5.According to with or without infringement of the pleura, P<0.05,two groups of VEGF-D and VEGFR-2 difference is statistically significant.
6.VEGF-D and VEGFR-2 expression levels in the lung cancer group are positively correlated (r=0.866 P<0.01).
Conclusions:VEGF-D and VEGFR-2 expression levels in the serum of patients with lung cancer are higher than in healthy control group, so the detection of serum VEGF-D and VEGFR-2 expression level on research of lung cancer early diagnosis,clinical staging,prognosis,there is a certain reference value.|
李永丽. 肺癌患者血清VEGF-D、VEGFR-2水平及 临床意义[D]. 兰州. 兰州大学,2013.
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