| 肺癌患者血清VEGF-D、VEGFR-2水平及 临床意义 |
| Alternative Title | Levels and Clinical Significance of VEGF-D and VEGFR-2 of the Serum in Lung Cancer
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| 李永丽 |
| Thesis Advisor | 蔡曦光
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| 2013-05-13
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | VEGF-D
VEGFR-2
肺癌
ELISA法
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| Abstract | 研究目的：检测肺癌患者血清中血管内皮生长因子D(VEGF-D)、血管内皮生长因子受体2(VEGFR-2)的表达；探讨VEGF-D与VEGFR-2的表达与肺癌临床病理特征的关系及其临床意义。
研究方法：采用ELISA法检测VEGF-D与VEGFR-2在52例肺癌组和36例健康对照组血清的表达情况。
研究结果：
1.肺癌组和正常对照组比较，小细胞肺癌组，非小细胞肺癌组，健康对照组血清VEGF-D、VEGFR-2水平由秩和检验得出P<0.05，三组差异有统计学意义。
2.肺癌组按照肿瘤分化程度分组后比较，三组患者血清中VEGF-D及VEGFR-2进行秩和检验，P<0.05，高分化组、中分化组及低分化组VEGF-D、VEGFR-2浓度差异有统计学意义。
3.肺癌组按照临床分期分组后比较，P＜0.05，两组血清中VEGF-D及VEGFR-2浓度差异有统计学意义。
4.肺癌组按照TNM分期分组后比较，P＜0.05，按照TNM分期分组后患者血清VEGF-D及VEGFR-2浓度差异有统计学意义。
5.肺癌组按照胸膜侵犯分组后比较，P＜0.05，两组血清中VEGF-D及VEGFR-2浓度差异有统计学意义。
6.肺癌组血清VEGF-D与VEGFR-2表达水平呈正相关(r=0.866 P<0.01)。
研究结论：肺癌患者血清中VEGF-D及VEGFR-2表达水平高于健康对照组，检测血清VEGF-D及VEGFR-2表达水平对研究肺癌的早期诊断、临床分期、预后判断有一定的参考价值。 |
| Other Abstract | Objective:To detect the serum vascular endothelial growth factor D (VEGF-D),vascular endothelial growth factor receptor 2 (VEGFR-2) levels of lung cancer patients;explore the relationship between VEGF-D and VEGFR-2 expression in lung cancer clinical and pathological features and its clinical significance.
Methods:VEGF-D and VEGFR-2 expression of serum in 52 cases of lung cancer and 36 cases of the healthy control group is detected by ELISA.
Results:
1.Comparison of lung cancer and control groups, the VEGF-D,VEGFR-2 levels of small cell lung cancer,non-small cell lung cancer patients and healthy controls derives by the rank-sum test P<0.05,the difference is statistically significant.
2.Comparison group of lung cancer patients in accordance with the degree of tumor differentiation,three groups of serum VEGF-D and VEGFR-2 compares by rank sum test, P<0.05, VEGF-D and VEGFR-2 concentration of well differentiated ,moderately differentiated and poorly differentiated are statistically significant.
3.In accordance with the clinical staging of lung cancer group is compared,P<0.05, difference in serum VEGF-D and VEGFR-2 of two groups are statistically significant.
4.According to the TNM stage lung cancer group is compared in two groups of patients with serum VEGF-D and VEGFR-2,P<0.05,according to the TNM stage grouping serum VEGF-D and VEGFR-2 difference is statistically significant.
5.According to with or without infringement of the pleura, P<0.05,two groups of VEGF-D and VEGFR-2 difference is statistically significant.
6.VEGF-D and VEGFR-2 expression levels in the lung cancer group are positively correlated (r=0.866 P<0.01).
Conclusions:VEGF-D and VEGFR-2 expression levels in the serum of patients with lung cancer are higher than in healthy control group, so the detection of serum VEGF-D and VEGFR-2 expression level on research of lung cancer early diagnosis,clinical staging,prognosis,there is a certain reference value. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/223574
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
李永丽. 肺癌患者血清VEGF-D、VEGFR-2水平及 临床意义[D]. 兰州. 兰州大学,2013.
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