| Other Abstract | Objective: To investigate the effect of dezocine alone or combined with dexmedetomidine in perioperative surgery.
Methods: This is a prospective, randomized, double-blind, and placebo controlled study．Sixty ASA I~II pediatric patients, aged (4~10)yrs, weighing (14~40)kg, scheduled for tonsillectomy and adenoidectomy were randomly divided into three groups (n=20 each): the control group (group C), multimodal analgesia group (group M) and the dezocine group (group D). Before induction, patients in group M started with intravenous infusion of dexmedetomidine (1μg/kg) for 10 minutes. After 10 min, dexmedetomidine (0.5μg·kg-1·h-1) were continually given to patients for 50min (in total 1h). Patients in group C and group D received the same volume of normal saline. Group D and group M received dezocine(0.1mg/kg) 15min before the end of surgery, group C received the same volume of normal saline. Vital signs were compared among the three groups at 10 time points: patient entering the operation room (T1), 5 minutes after intravenous infusion (T2), intubation (T3), extubation (T4), 5 minutes after extubation (T5), 1 hours(T6)、2 hours(T7)、4 hours(T8)、6 hours(T9)、24 hours(T10) after surgery. The duration of anesthesia and surgery, duration for anesthesia recovery and extubation, evaluation of postoperative agitation (EA)，postoperative pain, sedation score and adverse reactions at time points T6~T10were compared. Serum concentrations of substance P(SP), β-endorphin(β-EP), Orphanin FQ(OFQ) of children at T1、T6、T10 were measured as well.
Results: The general information and the duration of anesthesia, operation, anesthesia recovery period and extubation were not statistically different among the three groups（P>0.05）. Compared with group C（65%,3.2±1.0）, the incidence and the grading of EA were lower in group group D（30%,2.4±0.8）and M（10%,2.0±0.7）in anesthesia recovery period（P<0.05）Compared with group C(8.8±2.5,ml), the dosage of sevoflurane was significantly less in the group M (5.8±2.0,ml) during the surgery（P<0.05）. Compared with group C during T2~T9 and group D during T2~T8, the heart rate was significantly lower in group M（P<0.05）. Compared with group C and group D、T1 of group M, the SBP was significantly higher at T2 of group M （P<0.05）.Compared with group C, the VAS score during T6~T8, the FLACC score during T6~T9 were significantly lower in group D and group M（P<0.05）.Compared with group C, the Ramsay score of group D and ... |
