|Alternative Title||Research on changes of TPO and TSP-1 in children with Kawasaki disease and its significance
|Place of Conferral||兰州
|Other Abstract||Objectives: To observe the distribution of serum thrombopoietin , thrombospondin-1. platelet total and platelet parameters in children with Kawasaki disease and children in the control group, to explore deeply the law of changes of platelets，and relation between TPO, TSP-1 and changes of platelets, its potential mechanisms.
Methods：Serum TPO and serum TSP-1 were measured by Enzyme-linked immunosorbent assay, PLT and platelet parameters were measured by Automatic Hematology Analyzer in 32 cases of KD inpatients of pediatric department during September 1 st, 2011 and December 31st, 2012, 30 cases of children in similar ages in the control group were measured the same indicators during the same period，relative data were analyzed.
Results: (1) The level of serum TPO was highest in acute phase and decresed quickly then, while serum TSP-1 was highest in acute phase and decreased little by little; PLT reached the peak in sub-acute phase; The activity of platelet reached the strongest level in acute children with KD and decreased then.
(2) There was no correlation between the level of serum TPO and TSP-1 in acute and convalescent phase, positive correlation was showed in sub-acute KD children ; There was no correlation between the level of serum TPO and PLT in acute, sub-acute and convalescent phase; Similarly, there was no correlation between the level of serum TSP-1 and PLT in acute, sub-acute and convalescent phase.
Conclusions: (1) TPO functions as an acute phase reactant, the level of it is regulated by several factors in spite of the number of platelets.
(2) The number of platelets reaches highest in sub-acute children with KD, lagging behind the peak phase of serum TPO, which may paly an important role in regulation of the number of platelets.
(3) The level of serum TSP-1 was related to the activity of the platelet, it can be used as an indicator to evaluate the extent to which the activity of platelet reaches. The activity of platelet reaches the strongest in acute children with KD.|
刘路琼. 川崎病患儿血清TPO、TSP-1动态变化的研究及意义[D]. 兰州. 兰州大学,2013.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.