兰州大学机构库 >学院待认领
成人支气管哮喘特异性免疫治疗临床疗效的系统评价
Alternative TitleThe clinic effectiveness of specific immunotherapy for adult asthma: A systematic review
陈小雪
Thesis Advisor余勤
2008-04-27
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword支气管哮喘 特异性免疫治疗 系统评价
Abstract目的:探讨评价特异性免疫治疗(SIT)对成人支气管哮喘的临床疗效。 方法:利用计算机查找及筛选出pubmed(1966-2007、8)、cochrane图书馆(Issue 2,2007、8)、BMBASE(-2007、8)、VIP(1989-2007、8)、中国生物医学文献数据库(CBMDISC)(1978-2007、8)、中国学术期刊全文数据库(CJFD)(1979-2007、8)等数据库中所需的文献。并手工检索相关资料,检索本领域专家近年来使用特异性免疫疗法治疗哮喘病的研究成果。并对纳入的研究的方法学质量按Cochrane协作网推荐的方法进行了评价。 结果:共纳入10篇随机对照试验(298例患者),描述性分析表明:与安慰剂组比较,特异性免疫治疗能显著改善哮喘病人的临床症状且能减少患者对药物的需求量,在提高FEV1值方面效果显著。特异性免疫治疗对哮喘患者生活质量有明显的提高,以上结果均有统计学意义。 结论:特异性免疫治疗技术在哮喘研究中已趋于成熟,它能够改善患者的临床症状和肺部功能,并且能减少对药物的需求量。同时特异性免疫治疗的副反应(比如过敏反应)发生率低,推荐用于临床。
Other AbstractObjective To evaluate evidence on the clinical effectiveness of allergen specific immunotherapy for adult asthma. Methods Searching:PubMed,Embase,Cochrane library Chinese Biomedicine database and China Journal Fulltext Database et al.We handsearched the related published and unpublished data and their references.All trials about specific immunotherapy for asthma were included.The included studies were evaluated by two researchers independently. Results Ten RCTs involving 298 patients were included.The results of descriptive-analysis were listed as the following: There was a significant reduction in asthma symptoms and medication following immunotherapy.There was also consistent effect on quality of life. Conclusion The review of trial found that allergen specific immunotherapy can reduce asthma symptoms and the need for medications, improve the sensitivity of the lungs and have lower side-effects rate(such as anaphylaxis).
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223736
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
陈小雪. 成人支气管哮喘特异性免疫治疗临床疗效的系统评价[D]. 兰州. 兰州大学,2008.
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