兰州大学机构库 >学院待认领
参麦注射液治疗肿瘤放化疗后白细胞减少症的Meta分析
Alternative TitleEffectiveness of Shenmai Injection for Leukopenia after the Tumor Radiation and Chemotherapy:A Meta-Analysis
刘祥祥
Thesis Advisor席亚明
2014-05-19
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword参麦注射液 白细胞减少症 Mete分析 系统评价 随机对照试验
Abstract目的 系统评价参麦注射液治疗肿瘤放化疗后白细胞减少症(leukopenia)的疗效。 方法 计算机检索PubMed(1966~2013.6)、CochraneLibrary(2013年第5期)、Web of Science(1980~2013.6)、VIP(1989~2013.6)、WanFang Data(1990~2013.6)、CNKI(1980~2013.6)、CBM(1981~2013.6)数据库发表的关于参麦注射液治疗肿瘤放化疗患者白细胞减少症的随机对照试验(RCT)。由两位研究者独立进行文献筛选、资料提取和质量评价后,采用RevMan 5.2软件、Stata12.0软件进行Meta分析。 结果 共纳入11个研究,1009例患者。Mete分析结果显示:参麦注射液和常规口服升白药治疗肿瘤放化疗后白细胞减少症时,两者显效[RR=1.57,95%CI (1.39, 1.78),P<0.00001]、无效[RR=0.34,95%CI(0.25,0.47),P<0.00001]、以及总有效[RR= 1.27,95%CI (1.19, 1.36),P<0.00001]差异均有统计学意义;两者有效[RR=0.90,95%CI(0.74,1.09),P=0.27]差异无统计学意义。按照常规口服升白药的种类进行亚组分析,结果显示:参麦注射液的疗效优于常规口服升白药。 结论 参麦注射液治疗肿瘤放化疗后白细胞减少症的疗效优于常规口服升白药物。但受纳入研究的数量及质量限制,本系统评价结论仍需进一步开展更多大样本、严格设计的随机对照试验加以验证。 关键词:参麦注射液,白细胞减少症,Mete分析,系统评价,随机对照试验
Other AbstractObjective To systematically evaluate the effectiveness of shenmai injection for leukopenia a- fter the tumor radiation and chemotherapy. Methods Such databases as PubMed(1966 to June 2013),CochraneLibrary(Issue 5,2013),Web of Science(1980 to June 2013),VIP(1989 to June 2013),WanFang Data(1990 to June 2013),CNKI(1980 to June 2013),CBM(1981 to June 2013)were searched to collect the randomized controlled trials(RCTs) on shenmai injection in treating leukopenia after the tumor radiation and che- motherapy.Document selection and data fetch and the quality of included studies was evaluated by two reviewers in- dependently,and then meta-analyses were performed using Review Manager 5.2 software and Stata12.0 software. Results A total of eleven studies involving 1009 patients were included.Results of meta-analyses showed that when shenmai injection and normal oral drugs for rise leucocyte were used in the treatment of leukopenia after the tumor radiation and chemotherapy, significant differences were found in the significant effectiveness (RR=1.57,95%CI 1.39 to 1.78,P<0.00001), ineffectiveness(RR= 0.34,95%CI 0.25 to 0.47,P<0.00001) and total effectiveness (RR= 1.27 , 95%CI 1.19 to 1.36,P<0.00001), but no significant difference was found in effectiveness(RR=0.90,95%CI 0.74 to 1.09,P=0.27).The subgroup analyses were performed among different normal oral drugs showed that shenmai injection's curative effect was better than normal oral drugs. Conclusion In the effectiveness of treatment for leukopenia after the tumor radiation and chemotherapy,the shenmai injection is superior to normal oral drugs .However,all these findings should be further confirmed with more large sample and well-designed RCTs. Key words : Shenmai injection,Leucopenia,Meta-analysis,Systematic review,Randomized controlled trial
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223766
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
刘祥祥. 参麦注射液治疗肿瘤放化疗后白细胞减少症的Meta分析[D]. 兰州. 兰州大学,2014.
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