| 不同类型肾癌的CT表现与Ki67、MVD、P73 表达的相关性研究 | |
| Alternative Title | A correlative study between CT features and the expression of Ki67 and MVD ， P73 in different types of renal cell carcinoma |
| 杨毅 | |
| Subtype | 硕士 |
| Thesis Advisor | 周俊林 |
| 2013-05-20 | |
| Degree Grantor | 兰州大学 |
| Place of Conferral | 兰州 |
| Degree Name | 硕士 |
| Keyword | 计算机体层摄影 肾细胞癌 Ki67抗原 微血管密度 P73抗原 |
| Abstract | 探讨不同类型肾细胞癌的CT表现与Ki67、MVD、P73表达的相关性，通过肾癌的CT表现评价其部分生物学行为。收集我院近三年来手术病理证实的58例肾癌患者病例。所有病例均使用西门子Sensation 40排螺旋CT行双肾CT平扫及三期增强扫描，扫描过程在病人平静呼吸下屏气后进行。由两位副高以上放射科诊断专家对所有病例的强化程度、肿瘤大小、形态、钙化、出血、边界等情况进行双盲法分析。 不同肾癌亚型CT表现不同，通过MSCT扫描，不仅可以比较准确对肾细胞癌进行正确的术前诊断，同时可以对肾透明细胞癌、乳头状肾细胞癌、肾嫌色细胞癌、多房囊性肾癌、肾集合管癌等几种亚型进行比较准确的分型。 肾癌组织的Ki67、MVD、P73表达明显高于正常肾组织，对明确肾癌的诊断，评测其亚型的恶性程度都有较高价值。 肾癌亚型的CT征象与Ki67、MVD、P73的表达具有相关性，说明肾癌亚型的CT表现可能在一定程度反映出肿瘤的生物学特性。 |
| Other Abstract | To study the correlation between CT features and the expression of Ki67 and MVD ， P73 in different types renal cell carcinoma . So as to evaluate CT features of the subtypes of renal cancer and its biological behaviour. Methods To collect 52 cases with RCC which were confirmed by operation and pathology in nearly three years, including 30 cases of CCRCC, 12 cases of PRCC and 10 cases of CRCC. The Siemens Sensation 64 row spiral CT was used， 52 cases were examined through plain and enhanced scanning CT in three phases（including cortex phase，corticomedullary phase，excretory phase）. The total amount of 60-80ml iohexol（300mg／m1）were injected with high pressure injector at a flow rate 3～5ml/s.CT parameter were 120kv,pitch=1.2 and 8 mm layer thickness . The patients must hold their breath in the whole scan process. The biggest enhanced degrees，size，shape, calcification, hemorrhage, boundary of the tumors were analysed by two Radiology experts with double-blind method. The expression of MVD ，Ki67，P73 of the collected organic material were confirmed by Immunohistochemical staining.then analized the relationship between CT features and the expression of MVD and Ki67, P73. An accurate preoperative diagnosis and subtypes classification of RCC such as CCRCC,PRCC,CCRCC，MRCC，CDC can be made by MSCT scanning. The expression of Ki67, MVD, P73 is significantly higher in the RCC than normal kidney tissues, it have a high value to diagnose RCC and estimate the severity of the mass. Some of CT features of RCC subtypes have correlation with the expression of Ki67, MVD and P73, it illustrate that CT manifestation of RCC subtypes may reflect the biological characteristic of tumors partly. |
| URL | 查看原文 |
| Language | 中文 |
| Document Type | 学位论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/223788 |
| Collection | 学院待认领 |
| Affiliation | 临床医学院 |
| Recommended Citation GB/T 7714 | 杨毅. 不同类型肾癌的CT表现与Ki67、MVD、P73 表达的相关性研究[D]. 兰州. 兰州大学,2013. |
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