波动性葡萄糖加重人脐静脉内皮细胞内质网应激

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	波动性葡萄糖加重人脐静脉内皮细胞内质网应激
Alternative Title	Endoplasmic reticulum stress was enhanced due to fluctuated glucose in human umbilical vein endothelial cells
	赵军明
Thesis Advisor	汤旭磊
	2008-05-26
Degree Grantor	兰州大学
Place of Conferral	兰州
Degree Name	硕士
Keyword	人脐静脉内皮细胞葡萄糖内质网应激氧化应激白藜芦醇
Abstract	目的观察不同浓度葡萄糖及波动性葡萄糖对体外培养后人脐静脉内皮细胞（HUVEC）内质网应激的影响及白藜芦醇(RES)对波动性葡萄糖致人脐静脉内皮细胞氧化损伤的干预作用。结论高糖和低糖均引起人脐静脉内皮细胞氧化和抗氧化系统失衡，导致内质网应激，波动性葡萄糖加重人脐静脉内皮细胞的内质网应激。白藜芦醇在一定程度上缓解波动性葡萄糖引起的内质网应激和凋亡蛋白CHOP/GADD153的高表达，对葡萄糖波动引起的人脐静脉内皮细胞的损伤具有保护作用。
Other Abstract	Aim: To explore the effects of the different glucose concentration and the intermittent glucose on endoplasmic reticulum stress in human umbilical endothelial cells and the protective effect of resveratrol on human umbilical vein endothelial cells oxidative damage results from glucose. Conclusion: High glucose, low glucose and fluctuate glucose all induce endoplasmic reticulum stress and result in oxidation and antioxidant system imbalances in vascular endothelial cells. Fluctuate glucose has the more serious effect on vascular endothelial cells than low or high glucose. Resveratrol treatment could significantly relieve endoplasmic reticulum stress in vascular endothelial cells, and has a protective effect on the balance between oxidation and antioxidant system.
URL	查看原文
Language	中文
Document Type	学位论文
Identifier	https://ir.lzu.edu.cn/handle/262010/223802
Collection	学院待认领
Affiliation	临床医学院
Recommended Citation GB/T 7714	赵军明. 波动性葡萄糖加重人脐静脉内皮细胞内质网应激[D]. 兰州. 兰州大学,2008.

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