兰州大学机构库 >学院待认领
TGF-α和p63在男性尖锐湿疣及阴茎癌组织中表达的研究
Alternative TitleExpressive study of TGF-α and p63 in the lesions of male condyloma
张嫦娥
Thesis Advisor李文竹
2009-05-26
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword尖锐湿疣 阴茎癌 人类乳头瘤病毒 转化生长因子-α p63
Abstract【第一部分】 目的: 探讨转化生长因子(TGF)-α 和p63在尖锐湿疣(CA)发病机制中的作用。方法:用聚合酶链反应(PCR)技术对34例男性CA组织进行检测;将有HPV6/11型感染的CA组织和正常包皮组织15例进行免疫组化(SP)法染色。结果:34例CA标本中有26例HPV 6/11型感染,阳性率为76.92%;CA组织中TGF-a和p63阳性表达率均为92.31%(24/26)。TGF-α和p63的表达强度在CA和正常包皮组织之间均有统计学意义(P<0.05);TGF-α和p63间有相关性(相关系数 rs=0.556, P=0.003<0.05)。结论: CA感染中以HPV6/11型占多数;TGF-α和p63在CA发病中起一定作用。 【第二部分】 目的: 研究TGF-α和p63在阴茎癌(PC)发病机制中的作用。方法:用PCR技术对26例PC组织进行检测;将有HPV感染的PC组织和正常包皮组织15例进行免疫组化(SP法)染色。结果:26例PC标本中有20例HPV DNA阳性,阳性率为76.47%;PC组织中TGF-a和p63阳性表达率分别为90%(18/20),95%(19/20)。TGF-α和p63的表达程度在PC和正常包皮组织之间均有统计学意义(P<0.05);TGF-α和p63间有相关性(相关系数 rs=0.467, P=0.038<0.05)。结论: PC中以HPV感染占多数;TGF-α和p63在PC发病中起一定作用。
Other Abstract【Part Ⅰ】 Objective: To investigate the roles of transforming growth factor –alpha (TGF–α)and P63 in pathogenesis of Condyloma acuminatum(CA). Methods: Polymerase Chain Reaction(PCR)used to detect the infection of HPV 6/11 type in 34 male cases with CA ; Immunohistochemical (streptavidin /peroxidase SP) method tested the expressions of TGF-α and p63 both in CA lesions with HPV 6/11 type and in normal prepuce of 15 cases. Results: There were 26 positive specimens with HPV 6/11 type in 34 lesions, the detection rate was 76.47% (26/34); The positive rates of both TGF-α and p63 were 92.31% (24/26). There were statistical differences in the detections of both TGF-α and P63 between in CA and in normal prepuce (P<0.05); Spearman related analysis between TGF-a and p63 was correlation,(correlation coefficient rs=0.556, P=0.003<0.05). Conclusions: The infection of HPV 6/11 type accounts for majority in CA ; And TGF-α and p63 play certain roles in the development of CA. 【Part Ⅱ】 Objective: To approach the roles of TGF –α and p63 in pathogenesis of Penile carcinoma (PC). Methods: PCR used to detect the infection of HPV in 26 cases with PC ; Immunohistochemitry (SP) tested the expressions of TGF-α and p63 both in PC with HPV infections and in normal prepuce of 15 cases. Results: There were 20 positive specimens with HPV infections in 26 lesions, the detection rate was 76.92% (20/26); The positive rates of both TGF-α and p63 were 90% (18/20) and 95% (19/20) respectively. There were statistical differences in the expressions of both TGF-α and p63 between in PC and in normal prepuce(P<0.05); Spearman related analysis between TGF-a and p63 was correlation,(correlation coefficient rs=0.467, P=0.038<0.05). Conclusions: The infection of HPV accounts for majority in PC ; And TGF-α and p63 play certain roles in the development of PC.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/223900
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
张嫦娥. TGF-α和p63在男性尖锐湿疣及阴茎癌组织中表达的研究[D]. 兰州. 兰州大学,2009.
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