p38MAPK在葛根素、白藜芦醇促成骨细胞增殖、分化

兰州大学机构库 >学院待认领

	p38MAPK在葛根素、白藜芦醇促成骨细胞增殖、分化
Alternative Title	Effects of P38MAPK on the Proliferation、Differentiation and Inhibited Apoptosis of Murine Osteoblasts by Puerain and Resveratrol
	王晓晖
Thesis Advisor	汤旭磊
	2008-05-26
Degree Grantor	兰州大学
Place of Conferral	兰州
Degree Name	硕士
Keyword	p38MAPK 成骨细胞増殖分化凋亡 17β-雌二醇葛根素白藜芦醇
Abstract	目的探讨p38MAPK信号转导通路在17β-雌二醇（17β-E2）、葛根素（PUE）和白藜芦醇（RES）促成骨细胞（OB）增殖、分化、抑凋亡中的作用。结论 17β-E2 、PUE 和RES具有促进OB的增殖、分化、矿化和Ⅰ型胶原表达并抑制其凋亡作用，p38MAPK信号转导通路在17β-E2 、PUE 和RES促OB的分化、矿化和Ⅰ型胶原的表达过程中发挥重要作用，而对其促OB的增殖和抑制凋亡的作用无明显影响。
Other Abstract	Objective　To investigate the effects of p38MAPK on the proliferation、differentiation and inhibited apoptosis of murine osteoblasts by 17β-estradiol，puerain and resveratrol. Conclusion 17β-Estradiol，puerarin and resveratrol apparently stimulated the proliferation，differentiation，mineral nodes，calcium deposition， the collagen I mRNA expression and inhibited the apoptosis of murine osteoblast. P38MAPK signal transduction pathway plays an important role in the differentiation，mineral nodes， calcium deposition and the collagen I mRNA expression of murine osteoblast，but it has significant effect on the proliferation and inhibited the apoptosis of murine osteoblast.
URL	查看原文
Language	中文
Document Type	学位论文
Identifier	https://ir.lzu.edu.cn/handle/262010/223994
Collection	学院待认领
Affiliation	临床医学院
Recommended Citation GB/T 7714	王晓晖. p38MAPK在葛根素、白藜芦醇促成骨细胞增殖、分化[D]. 兰州. 兰州大学,2008.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh