兰州大学机构库 >学院待认领
OSAHS患者血清RhoA/ROCK-2通路的改变与肺动脉压发生的相关研究
Alternative TitleThe relationship of serum RhoA/ROCK-2 signal transduction pathway in patients with OSAHS and pulmonary hypertension.
胡梅叶
Thesis Advisor岳红梅
2010-05-10
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword阻塞性睡眠呼吸暂停低通气综合征 RhoA Rho associated kinase-2 肺动脉高压
Abstract目的:探讨RhoA/ROCK-2在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者肺动脉高压(PH)形成中的作用。 方法:选择经睡眠监测确诊的30例OSAHS患者作为实验组,同时选择与之性别、年龄、体重指数(BMI)相匹配的健康自愿者15例作为对照组;经彩色多普勒超声心动图测定肺动脉压力(PAP);检测血清RhoA/ROCK-2水平。 结果:OSAHS组PAP水平(33.97±15.48 mmHg)高于对照组(19.47±1.92 mmHg)(W=175.50,P<0.05);OSAHS合并PH者血清RhoA/ROCK-2水平(14.85±8.49/36.81±12.69 ng/ml)明显高于对照组(2.94±1.20/6.04±0.28 ng/ml)(W=120.00;W=121.00,P均<0.05);OSAHS不合并PH者血清RhoA/ROCK-2水平(10.43±3.10/22.31±16.10 ng/ml)低于OSAHS合并PH者(14.85±8.49/36.81±12.69 ng/ml),但仍高于对照组(2.94±1.20/6.04±0.28 ng/ml )(H=29.172;H=30.242,P均<0.05);相关分析显示OSAHS组无论是合并PH还是未合并PH,PAP和AHI呈正相关(rs =0.793, rs =0.887, P均<0.05),最低SpO2和PAP呈负相关(rs =-0.562,rs =-0.751,P均<0.05),血清RhoA/ROCK-2水平均与PAP呈正相关(rs =0.793, rs =0.887, P均<0.05),RhoA和ROCK-2水平亦呈正相关(rs =1.000,rs =1.000,P均<0.05)。 结论:OSAHS为肺动脉高压发生的独立危险因素,并且 RhoA/ROCK-2通路可能在OSAHS患者肺动脉高压的形成中起重要作用。
Other AbstractObjective: To explore the role of RhoA/Rho associated kinase-2 (RhoA/ROCK-2) in the development of pulmonary hypertension(PH) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: thirty patients diagnosed OSAHS in our sleep laboratoty by polysomnograshy(PSG) test were included in the study as the observation group ,and fifteen healthy subjects who were matched in Gender, Age and Body mass index (BMI) with OSAHS group were recruited as the control group. Pulmonary arterial pressure was measured by echocardiography. The serum RhoA/ROCK-2 levels were measured. Results: The level of PAP in patients with OSAHS(33.97±15.48 mmHg) was higher than that in the control group(19.47±1.92 mmHg) (W=175.50,P<0.05), and there was a positive correlation between PAP and AHI in patients with OSAHS(rs =0.793, rs =0.887, P<0.05). The level of LSaO2 in patients with OSAHS(92.80±1.89%) was lower than that in the control group (66.17±13.44%) (W=435.00,P<0.05), and there was a negative correlation between PAP and LSaO2 in patients with OSAHS(rs =-0.562,rs =-0.751, P<0.05).The level of RhoA/ROCK-2 in OSAHS patients with PH (14.85±8.49/36.81±12.69 ng/ml)was higher than that in the control group(2.94±1.20/6.04±0.28 ng/ml) (W=120.00;W=121.00,P<0.05). The level of RhoA/ROCK-2 in OSAHS patients without PH(10.43±3.10/22.31±16.10 ng/ml) was lower than that in OSAHS patients with PH(14.85±8.49/36.81±12.69 ng/ml), but higher than that in the control group(2.94±1.20/6.04±0.28 ng/ml) (H=29.172;H=30.242,P<0.05). There were positive correlations between the level of RhoA/ROCK-2 and PAP in patients with OSAHS(rs =0.793, rs =0.887, P<0.05). Finally,there was a positive correlation between the level of RhoA and ROCK-2 in patients with OSAHS(rs =1.000,rs =1.000,P<0.05). Conclusion: OSAHS is an independent risk factorfor for pulmonary hypertension.The levels of serum RhoA/ROCK-2 in OSAHS patients with PH were increased in the development of the disease. It may play an important role in the process of pulmonary hypertension in patients with OSAHS.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/224000
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
胡梅叶. OSAHS患者血清RhoA/ROCK-2通路的改变与肺动脉压发生的相关研究[D]. 兰州. 兰州大学,2010.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[胡梅叶]'s Articles
Baidu academic
Similar articles in Baidu academic
[胡梅叶]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[胡梅叶]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.