兰州大学机构库 >学院待认领
HE4在卵巢上皮性癌早期诊断及病情监测中的价值
Alternative TitleDiagnostic and Prognostic Value of Serum HE4 in Patients with Epithelial Ovarian Cancer
宋晓玲
Thesis Advisor杨毓琴
2012-05-17
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword卵巢上皮性癌 肿瘤标志物 早期诊断
Abstract目的 本实验应用ELISA方法检测卵巢肿瘤患者及健康体检者HE4水平,结合临床资料回顾分析,探讨HE4在卵巢癌尤其是早期卵巢癌诊断及病情监测中的意义。 方法 选择2010年07月至2011年07月甘肃省人民医院妇科住院的卵巢癌初治患者36例,卵巢良性肿瘤患者48例,健康体检中心健康女性体检者32例。应用双抗夹心法检测HE4和CA125水平。 结论 1卵巢癌患者HE4水平明显高于良性卵巢肿瘤及健康女性;卵巢癌患者HE4水平与患者的病理分期有关。 2 HE4诊断卵巢癌有较高的特异性和敏感性,对卵巢癌与卵巢良性肿瘤鉴别诊断的特异性相比CA125高,有望成为诊断卵巢癌的血清肿瘤标记物 3术后的卵巢癌患者HE4水平较术前明显降低,HE4作为卵巢癌疗效评价及病情监测具有可行性。
Other AbstractObjectives:In this experimental,serum HE4 was determined by enzyme-linked immunosorbent assay in samples from overian tumor patients and healthy female volunteers. Methods: We recruited 36 primary epithelial ovarian cancer patients,48 patients of ovarian benign masses and 32 healthy volunteers during July 2010 to July 2011 from the gynecology-oncology 1 ovarian cancer were higher than the group of benign ovarian tumors and healthy volunteers. However, the HE4 was no significant difference between ovarian benign tumor patients and healthy volunteers. 2 It is no sinificant difference between the histologic subtypes of ovarian cancer. 3 The serum HE4 values measured in stage Ⅲ-ⅣEOC patients were higher than in stage Ⅰ-Ⅱ EOC patients. Conclusions: 1 Serum HE4 level that was evaluated by ELISA kit of overian cancer were higher than in benign overian tumors and healthy volunteers. 2 serum HE4 has a higher sensitivity and specificity than CA125. 3 The serum HE4 after surgery was significantly lower compared with preoperative. Key words: Epithelial ovarian cancer, tumor marker,early diagnosis
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Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/224108
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
宋晓玲. HE4在卵巢上皮性癌早期诊断及病情监测中的价值[D]. 兰州. 兰州大学,2012.
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