|Role of Ghrelin in Head Injury Complicating with AGML
|Place of Conferral
|Objective： Recent studies revealed that Ghrelin exhibit gastroprotective activity against gastric mucosal lesions induced by stress. Previous reports demonstrated that incidence rate of acute gastric mucosal lesion (cushing’s ulcer) in the patients underwent severe head injury, Since Ghrelin exhibit gastroprotective activity against gastric mucosal lesions induced by stress, we detect clinical variables of plasma Ghrelin level in mild、moderate and severe head injury as well as in healthy control for investigating the regularity of Ghrelin in head injury and authenticating whether Ghrelin exhibit gastroprotective activity in severe head injury.
Materials and Methods： Sixty consecutive patients (21 women and 39 men; mean age 36 years, range 7-71 years) with isolated head injury seen within the first five hours of the trauma prior to treatment and 20 fasting volunteers (6 women and 14 men; mean age 37 years, range 29-43 years) were included in the study. The gastrofiberscope check, the fecal occult blood (FOB) and the gastric occult blood (GOB) were recorded. According to the checks, head injury group were divided into AGML group and nonAGML group. Collect blood samples into the Lavender Vacutaner tubes which contain EDTA and aprotinin, then gently rock tubes several times immediately. After centrifuging the blood, collect the plasma. Plasma was kept at -70°C for detection. Ghrelin of all the subjects were detected by ELISA.
Results： Plasma Ghrelin concentration was significantly higher in severe head injury than in mild and moderate head injury as well as in healthy control. But plasma Ghrelin concentration in mild and moderate head injury was not related to healthy control.
Conclusions： The present research is the first evidence to elucidate that plasma Ghrelin concentration is significantly increased in severe head injury but not in mild and moderate head injury as well as in healthy control, and significantly higher in head injury complicating with AGML than nonAGML, which indicate that endogenous Ghrelin might exert a potent gastroprotective activity in cushing’s ulcer provoked by severe head injury.
袁光. Ghrelin在颅脑损伤及并发AGML中的作用[D]. 兰州. 兰州大学,2008.
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