| FEV3/FVC在判断早期气道阻塞中的应用研究 |
| Alternative Title | The study of FEV3/FVC in detecting early airway obstruction
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| 沈冰晓 |
| Thesis Advisor | 万毅新
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| 2015-05-26
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| Degree Grantor | 兰州大学
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| Place of Conferral | 兰州
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| Degree Name | 硕士
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| Keyword | FEV3
FEV3/FVC
气道阻塞
小气道
肺功能
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| Abstract | 目的：探讨FEV3<下标!>/FVC在判断早期气道阻塞中的诊断作用，为床应用增加新的更敏感的指标提供依据。方法：对2014年11月—2015年1月于兰州大学第二医院肺功能室行肺功能检查的检查者的肺功能结果进行统计分析。根据检查结果，分为三组：A组（FEV1<下标!>/FVC 和FEV3<下标!>/FVC均正常）、B组（仅FEV3<下标!>/FVC降低）、C组（FEV1<下标!>/FVC降低），比较各组肺通气功能指标、弥散功能指标、肺容量、小气道功能指标的结果并分析FEV3<下标!>/FVC与小气道功能指标的相关性，计算FEV3<下标!>/FVC判断气道阻塞作用的敏感度、特异度、阳性预测值、阴性预测值。结果：B组与A组比较，其TLC%预计值、RV%预计值、RV/TLC较A组升高，FEV1<下标!>%预计值、IC%预计值、DL<下标!>CO%预计值降低，P<0.05。B组与C组比较，其TLC%预计值、RV%预计值、RV/TLC的值较小，而FEV1<下标!>%预计值、IC%预计值、DL<下标!>CO%预计值较C组大，P<0.05。FEV3<下标!>/FVC与MMEF、FEF50%<下标!>FEF75%<下标!>呈正相关，相关系数分别为0.602、0.567、0.637P<0.001。FEV3<下标!>/FVC判断气道阻塞作用的敏感度、特异度、阳性预测值、阴性预测值分别为94.4%、61.7%、37.4%、97.9%。结论：FEV3<下标!>/FVC下降可提示早期气道阻塞或小气道病变的可能。FEV3<下标!>/FVC可以与FEV1<下标!>/FVC一起共同成为常规肺通气功能检查的指标。 |
| Other Abstract | Objective: To study the significance of FEV3<下标!>/FVC for detecting early airway obstruction or small airway disease,and add a new more sensitive index for clinical diagnosis.Methods: 370 cases of pulmonary function test results were involved in this statistical analysis.The pulmonary function test was inspected in Lanzhou university second hospital from Nov.2014 to Jan. 2015. The results were divided into three groups:(A) normal FEV1<下标!>/FVC and FEV3<下标!>/FVC;B)only a reduced FEV3<下标!>/FVC;(C)reduced FEV1<下标!>/FVC.Compare the differences of the lung function indexes for the three group.Spearman correlation determined the relationships between FEV3<下标!>/FVC and small airway indexex.And calculate the sensitivity,specificity,positive predictive value and negative predictive value of FEV3<下标!>/FVC for judging the airway obstruction.Results: Compared with group A，group B had higher % predicted TLC,residual volume (RV)，and RV/TLC %,and lower % predicted FEV1<下标!>,inspiratory capacity(IC) and diffusing capacity of lung for carbon monoxide (DL<下标!>CO),P <0.05 . Compared with group C,group B had lower % predicted TLC,RV,and RV/TLC %,and higher % predicted FEV1<下标!>,IC and DL<下标!>CO，P <0.05 .FEV3<下标!>/FVC was correlated positively with MMEF（r =0.602，P <0.001）, MEF50<下标!>（r =0.567，P <0.001）and MEF25<下标!>（r =0.637,P <0.001）. The sensitivity ,specificity,positive predictive value and negative predictive value of FEV3<下标!>/FVC for judging the airway obstruction is 94.4%,61.7%，37.4%,97.9% respectively.
Conclusions: The reduction of FEV3<下标!>/FVC may indicate an early airway obstruction and small airway disease. The FEV3<下标!>/FVC should be routinely reported with FEV1<下标!>/FVC in lung function test. |
| URL | 查看原文
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| Language | 中文
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| Document Type | 学位论文
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| Identifier | https://ir.lzu.edu.cn/handle/262010/224134
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| Collection | 学院待认领
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| Affiliation | 临床医学院
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Recommended Citation
GB/T 7714 |
沈冰晓. FEV3/FVC在判断早期气道阻塞中的应用研究[D]. 兰州. 兰州大学,2015.
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