兰州大学机构库 >学院待认领
2007~2010年间嗜血杆菌感染现状及耐药性研究
Alternative TitleStudy on the infection status and antibiotics -resistance of Haemophilus isolated from 2007 to 2010
贾晨路
Thesis Advisor金凤玲
2011-05-16
Degree Grantor兰州大学
Place of Conferral兰州
Degree Name硕士
Keyword嗜血杆菌 耐药率 β-内酰胺酶 多重耐药 临床分布
Abstract目的 了解2007~2010年间本地区嗜血杆菌的分布和耐药情况,为嗜血杆菌感染控制和临床合理用药提供依据。 方法 对2007~2010年间我院41811份非粪便标本进行嗜血杆菌的分离培养,采用头孢硝噻吩法检测β-内酰胺酶,K-B法对11种常用抗菌药物进行体外药敏试验,WHONET5.5和SPSS17.0软件进行数据处理,分析其感染现状及耐药模式。 结果 41811份非粪便标本共分离出嗜血杆菌1573株,总检出率为3.76%,主要来自呼吸道标本,40.24%的嗜血杆菌分离自呼吸科;其中流感嗜血杆菌610株,副流感嗜血杆菌956株,溶血嗜血杆菌6株,副嗜沫嗜血杆菌1株;2010年副流感嗜血杆菌的检出率高于2007~2009年,但其耐药性并无差别;各季节之间嗜血杆菌的分离率有明显差异,以冬季为最高;β-内酰胺酶的阳性率为33.00%,氨苄西林耐药β-内酰胺酶阳性的菌株408株,氨苄西林耐药β-内酰胺酶阴性的菌株109株;BLPAR对氨苄西林/舒巴坦、阿莫西林/克拉维酸、头孢呋辛、氨曲南四种抗菌药物的敏感率均高于BLNAR,而BLNAR对阿奇霉素的敏感率则高于BLPAR。药敏试验显示嗜血杆菌对氨苄西林和复方新诺明的耐药率分别为37.7%和42.4%,对头孢曲松(CRO)、阿奇霉素(AZM)、美罗培南(MEM),左氧氟沙星(LEV)和氨曲南(ATM)的不敏感率变化为1.1%~26.3%,且对这五种抗菌药物的多重耐药主要以LEV+AZM+ATM三联耐药模式为主;
Other AbstractObjective To investigate the distribution and antibiotic resistance of Haemophilus ,so as to provide a basis for controlling hospital infection and using antibiotics properly. Method Haemophilus were isolated and cultured from a total of 41811 specimens except feces in our hospital from 2007 to 2010. Nitrocefin test was used to detect β-laetamase. Susceptibility tests to eleven antibiotics were carried out. Data was analysised by WHONET5.5 and SPSS17.0 software.The infection status and antibiotics-resistance patterns of Haemophilus was analysised. Result A total of 1573 strains of Haemophilus were isolated from 41811 specimens except feces, most of which were isolated from patients with respiratory infection and 40.24% isolated from Pneumology Department,and the detected rate accounted for 3.76%,in which Haemophilus influenzaes accounted for 610,Haemophilus parainfluenzaes 956, Haemophilus haemolyticus 6, Haemophilus paraphrophilus 1; The detected rate of Haemophilus parainfluenzae isolated from 2010 was higher than that from 2007 to 2009, but there was no difference in antibiotics-resistance.There was statistically significant difference in isolation rate of Haemophilus among four seasons, the infection rate in winter was higher than that in spring ,summer and autumn. The β-lactamase-positive rate was 33.00%, 408 β-lactamase-positive strains were resistant to ampicillin , 109 β-lactamase-negative strains were resistant to ampicillin; The sensitive rates of BLPAR to ampicillin/sulbatan ,amoxicillin/clavulanic acid,cefuroxime and Aztreonam were all higher than that of BLNAR, and the sensitive rate of BLNAR to azethromycin was higher than that of BLPAR. The resistance rates of Haemophilus to ampicillin and SMZ+TMP were 37.7%,42.4% ,respectively.
URL查看原文
Language中文
Document Type学位论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/224296
Collection学院待认领
Affiliation临床医学院
Recommended Citation
GB/T 7714
贾晨路. 2007~2010年间嗜血杆菌感染现状及耐药性研究[D]. 兰州. 兰州大学,2011.
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