|Alternative Title||Study on the infection status and antibiotics -resistance of Haemophilus isolated from 2007 to 2010
|Place of Conferral||兰州
|Abstract||目的 了解2007～2010年间本地区嗜血杆菌的分布和耐药情况，为嗜血杆菌感染控制和临床合理用药提供依据。 方法 对2007～2010年间我院41811份非粪便标本进行嗜血杆菌的分离培养，采用头孢硝噻吩法检测β-内酰胺酶，K-B法对11种常用抗菌药物进行体外药敏试验，WHONET5.5和SPSS17.0软件进行数据处理，分析其感染现状及耐药模式。
|Other Abstract||Objective To investigate the distribution and antibiotic resistance of Haemophilus ,so as to provide a basis for controlling hospital infection and using antibiotics properly.
Method Haemophilus were isolated and cultured from a total of 41811 specimens except feces in our hospital from 2007 to 2010. Nitrocefin test was used to detect β-laetamase. Susceptibility tests to eleven antibiotics were carried out. Data was analysised by WHONET5.5 and SPSS17.0 software.The infection status and antibiotics-resistance patterns of Haemophilus was analysised.
Result A total of 1573 strains of Haemophilus were isolated from 41811 specimens except feces, most of which were isolated from patients with respiratory infection and 40.24% isolated from Pneumology Department,and the detected rate accounted for 3.76%,in which Haemophilus influenzaes accounted for 610,Haemophilus parainfluenzaes 956, Haemophilus haemolyticus 6, Haemophilus paraphrophilus 1; The detected rate of Haemophilus parainfluenzae isolated from 2010 was higher than that from 2007 to 2009, but there was no difference in antibiotics-resistance.There was statistically significant difference in isolation rate of Haemophilus among four seasons, the infection rate in winter was higher than that in spring ,summer and autumn. The β-lactamase-positive rate was 33.00%, 408 β-lactamase-positive strains were resistant to ampicillin , 109 β-lactamase-negative strains were resistant to ampicillin; The sensitive rates of BLPAR to ampicillin/sulbatan ,amoxicillin/clavulanic acid,cefuroxime and Aztreonam were all higher than that of BLNAR, and the sensitive rate of BLNAR to azethromycin was higher than that of BLPAR. The resistance rates of Haemophilus to ampicillin and SMZ+TMP were 37.7%,42.4% ,respectively.|
贾晨路. 2007～2010年间嗜血杆菌感染现状及耐药性研究[D]. 兰州. 兰州大学,2011.
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