兰州大学机构库
Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4
2019-06-18
Source PublicationCell Reports   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN2211-1247
Volume27Issue:12Pages:3473-+
page numbers18
AbstractReprogramming somatic cells to pluripotency by Oct4, Sox2, Klf4, and Myc represent a paradigm for cell fate determination. Here, we report a combination of Jdp2, Jhdm1b, Mkk6, Glis1, Nanog, Essrb, and Sall4 (7F) that reprogram mouse embryonic fibroblasts or MEFs to chimera competent induced pluripotent stem cells (iPSCs) efficiently. RNA sequencing (RNA-seq) and ATAC-seq reveal distinct mechanisms for 7F induction of pluripotency. Dropout experiments further reveal a highly cooperative process among 7F to dynamically close and open chromatin loci that encode a network of transcription factors to mediate reprogramming. These results establish an alternative paradigm for reprogramming that may be useful for analyzing cell fate control.
PublisherCELL PRESS
DOI10.1016/j.celrep.2019.05.068
Indexed BySCIE
Language英语
Funding ProjectInternational Partnership Program of Chinese Academy of Sciences[154144KYSB20160059]
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000471867200006
PublisherCELL PRESS
Original Document TypeArticle
PMID 31216469
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/294537
Collection兰州大学
物理科学与技术学院
Corresponding AuthorLiu, Jing; Pei, Duanqing
Affiliation
1.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, South China Inst Stem Cell Biol & Regenerat Med, CAS Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China
2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Stem Cell & Regenerat Med, South China Stem Cell & Regenerat Med, Guangzhou 510530, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
5.Guangzhou Med Univ, Guangzhou Inst Biomed & Hlth, Chinese Acad Sci, Joint Sch Life Sci, Guangzhou 510530, Guangdong, Peoples R China
6.Lanzhou Univ, Sch Phys Sci & Technol, Lanzhou 730000, Gansu, Peoples R China
7.Chinese Acad Sci, Supercomp Ctr, Guangzhou Branch, Guangzhou 510530, Guangdong, Peoples R China
8.GIBH, Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510530, Guangdong, Peoples R China
9.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangzhou 510100, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Bo,Wu, Linlin,Li, Dongwei,et al. Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4[J]. Cell Reports,2019,27(12):3473-+.
APA Wang, Bo.,Wu, Linlin.,Li, Dongwei.,Liu, Yuting.,Guo, Jing.,...&Pei, Duanqing.(2019).Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4.Cell Reports,27(12),3473-+.
MLA Wang, Bo,et al."Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4".Cell Reports 27.12(2019):3473-+.
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