|The value of intracranial pressure combined with bispectral Index and blood markers monitoring the condition and prognosis of patients with severe traumatic brain injury
|Place of Conferral
|Objective: This study by monitoring in patients with severe traumatic brain injury in bispectral Index、intracranial pressure and the change of the concentration of brain damage markers, to explore its relationship with the condition and prognosis .Methods:To collect the second hospital of lanzhou university, craniocerebral trauma ward in September 2016 to September 2018 in patients with severe traumatic brain injury admitted to the hospital, according to the GCS score divided into highly-severe group 20 people (GCS3～5) and severe group 40 people (GCS6～8), within 7 days after injury in patients with continuous monitoring of intracranial pressure and bispectral Index, and evaluation of patients with GCS score and brain injury blood markers (NSE GFAP and uch-l1), and follow-up was conducted at 6 months after injury. According to GOS scores divided the patients into groups (GOS4～5) good prognosis and bad prognosis group (GOS1～3), with SPSS21.0 statistical software data processing .Results:The intracranial pressure and blood marker concentration of the Highly-severe group were significantly higher than that of the severe group within 7 days after injury, while the bispectral Index was lower than that of the severe group, and the difference between the two groups was statistically significant (P<0.05). There was a negative correlation between intracranial pressure and bispectral Index (r=-0.47,P<0.05), that is, the higher the intracranial pressure was, the lower the bispectral Index was. There were significant differences in intracranial pressure / bispectral Index and cerebral blood markers between the poor prognosis group and the good prognosis group (P<0.05).Conclusion:Invasive intracranial pressure blood/ biomarkers of brain injury and bispectral Index monitoring from a different perspective of physiology, to track the changes of craniocerebral trauma patients in real time, the more severe craniocerebral injury, the higher intracranial pressure and the concentration of blood markers ,at the same time, bispectral Index is lower, and the prognosis is poorer. therefore, combined intracranial pressure /blood biomarkers of brain injury and bispectral Index monitoring enhance the judgment of the condition and prognosis of patients with severe craniocerebral injury.
|First Author Affilication
|Second Clinical School
薛鑫. 颅内压联合脑电双频指数和血液标志物监测对重度颅脑损伤患者病情及预后的价值[D]. 兰州. 兰州大学,2019.
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