兰州大学机构库
Pain-Evoked Reorganization in Functional Brain Networks
Zheng, WH(郑炜豪)1,2; Woo, Choong-Wan3,4; Yao, ZJ(姚志军)1; Goldstein, Pavel5,6,7; Atlas, Lauren Y.8,9,10; Roy, Mathieu11; Schmidt, Liane12; Krishnan, Anjali13; Jepma, Marieke14; Hu, B(胡斌)1; Wager, Tor D.5,6,15
2020-05
Source PublicationCEREBRAL CORTEX   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN1047-3211
EISSN1460-2199
Volume30Issue:5Pages:2804-2822
page numbers19
AbstractRecent studies indicate that a significant reorganization of cerebral networks may occur in patients with chronic pain, but how immediate pain experience influences the organization of large-scale functional networks is not yet well characterized. To investigate this question, we used functional magnetic resonance imaging in 106 participants experiencing both noxious and innocuous heat. Painful stimulation caused network-level reorganization of cerebral connectivity that differed substantially from organization during innocuous stimulation and standard resting-state networks. Noxious stimuli increased somatosensory network connectivity with (a) frontoparietal networks involved in context representation, (b) "ventral attention network" regions involved in motivated action selection, and (c) basal ganglia and brainstem regions. This resulted in reduced "small-worldness," modularity (fewer networks), and global network efficiency and in the emergence of an integrated "pain supersystem" (PS) whose activity predicted individual differences in pain sensitivity across 5 participant cohorts. Network hubs were reorganized ("hub disruption") so that more hubs were localized in PS, and there was a shift from "connector" hubs linking disparate networks to "provincial" hubs connecting regions within PS. Our findings suggest that pain reorganizes the network structure of large-scale brain systems. These changes may prioritize responses to painful events and provide nociceptive systems privileged access to central control of cognition and action during pain.
Keywordfunctional network hub disruption inter-system connectivity immediate pain reorganization
PublisherOXFORD UNIV PRESS INC
DOI10.1093/cercor/bhz276
Indexed BySCIE ; SSCI
Language英语
Funding ProjectNational Institutes of Health[R01 MH076136] ; National Key Basic Research and Development Program of China[2014CB744600] ; National Natural Science Foundation of China[61210010][61632014] ; Program of Beijing Municipal Science and Technology Commission[Z171100000117005] ; China Scholarship Council[201606180117] ; Postdoctoral Funding of Zhejiang Province, China[514000-X81901]
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000535907200007
PublisherOXFORD UNIV PRESS INC
Original Document TypeArticle
PMID 31813959
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/405580
Collection兰州大学
信息科学与工程学院
Corresponding AuthorHu, Bin; Wager, Tor D.
Affiliation
1.Lanzhou Univ, Sch Informat Sci & Engn, Feiyun Bldg 427,222 Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China
2.Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Minist Educ, Key Lab Biomed Engn, Hangzhou 310027, Peoples R China
3.Ctr Neurosci Imaging Res, Inst Basic Sci, Suwon 16419, South Korea
4.Sungkyunkwan Univ, Dept Biomed Engn, Suwon 16419, South Korea
5.Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA
6.Univ Colorado, Inst Cognit Sci, Boulder, CO 80309 USA
7.Univ Haifa, Sch Publ Hlth, IL-3498838 Haifa, Israel
8.NIH, Natl Ctr Complementary & Integrat Hlth, Bldg 10, Bethesda, MD 20892 USA
9.NIMH, NIH, Bethesda, MD 20892 USA
10.NIDA, NIH, Baltimore, MD 21224 USA
11.McGill Univ, Dept Psychol, Montreal, PQ H3A 0G4, Canada
12.Sorbonne Univ, CNRS, INSERM, Inst Cerveau & Moelle Epiniere ICM,Control Intero, F-75013 Paris, France
13.CUNY Brooklyn Coll, Dept Psychol, Brooklyn, NY 11210 USA
14.Univ Amsterdam, Dept Psychol, NL-1018 WS Amsterdam, Netherlands
15.Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA
First Author AffilicationSchool of Information Science and Engineering
Corresponding Author AffilicationSchool of Information Science and Engineering
First Signature AffilicationSchool of Information Science and Engineering
Recommended Citation
GB/T 7714
Zheng, Weihao,Woo, Choong-Wan,Yao, Zhijun,et al. Pain-Evoked Reorganization in Functional Brain Networks[J]. CEREBRAL CORTEX,2020,30(5):2804-2822.
APA Zheng, Weihao.,Woo, Choong-Wan.,Yao, Zhijun.,Goldstein, Pavel.,Atlas, Lauren Y..,...&Wager, Tor D..(2020).Pain-Evoked Reorganization in Functional Brain Networks.CEREBRAL CORTEX,30(5),2804-2822.
MLA Zheng, Weihao,et al."Pain-Evoked Reorganization in Functional Brain Networks".CEREBRAL CORTEX 30.5(2020):2804-2822.
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