兰州大学机构库
Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics
2020-04
Source PublicationJOURNAL OF CLINICAL MEDICINE   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
EISSN2077-0383
Volume9Issue:4
page numbers30
AbstractViruses are widely used as a platform for the production of therapeutics. Vaccines containing live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key examples of clinically-approved therapeutic uses for viruses. Despite this, the use of virus-derived proteins as natural sources for immune modulators remains in the early stages of development. Viruses have evolved complex, highly effective approaches for immune evasion. Originally developed for protection against host immune responses, viral immune-modulating proteins are extraordinarily potent, often functioning at picomolar concentrations. These complex viral intracellular parasites have "performed the R&D", developing highly effective immune evasive strategies over millions of years. These proteins provide a new and natural source for immune-modulating therapeutics, similar in many ways to penicillin being developed from mold or streptokinase from bacteria. Virus-derived serine proteinase inhibitors (serpins), chemokine modulating proteins, complement control, inflammasome inhibition, growth factors (e.g., viral vascular endothelial growth factor) and cytokine mimics (e.g., viral interleukin 10) and/or inhibitors (e.g., tumor necrosis factor) have now been identified that target central immunological response pathways. We review here current development of virus-derived immune-modulating biologics with efficacy demonstrated in pre-clinical or clinical studies, focusing on pox and herpesviruses-derived immune-modulating therapeutics.
Keywordvirus immune modulation protein serpin chemokine binding protein chemokine growth factor cytokine interleukin therapeutic biologic
PublisherMDPI
DOI10.3390/jcm9040972
Indexed BySCIE
Language英语
Funding ProjectNIH[1R01AI100987-01A1][1RC1HL100202] ; American Heart Association[17GRNT33460327] ; University of Florida Gatorade Fund[00115070]
WOS Research AreaGeneral & Internal Medicine
WOS SubjectMedicine, General & Internal
WOS IDWOS:000531821000079
PublisherMDPI
Original Document TypeReview
PMID 32244484
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/406196
Collection兰州大学
Corresponding AuthorLucas, Alexandra R.
Affiliation
1.Arizona State Univ, Biodesign Inst, Ctr Personalized Diagnost, Tempe, AZ 85281 USA
2.Arizona State Univ, Ctr Immunotherapy Vaccines & Virotherapy, Biodesign Inst, Tempe, AZ 85281 USA
3.Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, Tongji Med Coll, Wuhan 430030, Peoples R China
4.Univ Otago, Dunedin 9054, New Zealand
5.Univ Florida, Dept Ophthalmol, Gainesville, FL 32610 USA
6.McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8S 4L8, Canada
7.Lanzhou Univ, Hosp 2, Dept Tumor Surg, Lanzhou 730030, Peoples R China
8.Univ Florida, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA
9.CSIC, Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain
10.Univ Autonoma Madrid, Madrid 28049, Spain
11.Creighton Univ, Dign Hlth, St Joseph Hosp, Phoenix, AZ 85013 USA
Recommended Citation
GB/T 7714
Yaron, Jordan R.,Zhang, Liqiang,Guo, Qiuyun,et al. Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics[J]. JOURNAL OF CLINICAL MEDICINE,2020,9(4).
APA Yaron, Jordan R..,Zhang, Liqiang.,Guo, Qiuyun.,Burgin, Michelle.,Schutz, Lauren N..,...&Lucas, Alexandra R..(2020).Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics.JOURNAL OF CLINICAL MEDICINE,9(4).
MLA Yaron, Jordan R.,et al."Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics".JOURNAL OF CLINICAL MEDICINE 9.4(2020).
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