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Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes
Wang, HaiYang1,2,3; Li, Yizeng4,5; Yang, J(杨靖)5,6; Duan, Xing1,2; Kalab, Petr2; Sun, Sean X.5; Li, Rong1,2,3
2020
Source PublicationScience Advances   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN23752548
Volume6Issue:14
page numbers16
AbstractPatterned cell divisions require a precisely oriented spindle that segregates chromosomes and determines the cytokinetic plane. In this study, we investigated how the meiotic spindle orients through an obligatory rotation during meiotic division in mouse oocytes. We show that spindle rotation occurs at the completion of chromosome segregation, whereby the separated chromosome clusters each define a cortical actomyosin domain that produces cytoplasmic streaming, resulting in hydrodynamic forces on the spindle. These forces are initially balanced but become unbalanced to drive spindle rotation. This force imbalance is associated with spontaneous symmetry breaking in the distribution of the Arp2/3 complex and myosin-II on the cortex, brought about by feedback loops comprising Ran guanosine triphosphatase signaling, Arp2/3 complex activity, and myosin-II contractility. The torque produced by the unbalanced hydrodynamic forces, coupled with a pivot point at the spindle midzone cortical contract, constitutes a unique mechanical system for meiotic spindle rotation.
Copyright © 2020 The Authors.
PublisherAMER ASSOC ADVANCEMENT SCIENCE
DOI10.1126/sciadv.aaz5004
Indexed BySCIE ; EI
Language英语
Funding ProjectNational Institutes of Health[RO1 HD086577]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000523302400032
PublisherAmerican Association for the Advancement of Science
EI Accession Number20201608433914
EI KeywordsCell proliferation ; Hydrodynamics ; Mammals ; Rotation
EI Classification NumberBiological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Mechanics:931.1
Original Document TypeJournal article (JA)
PMID 32284983
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/416747
Collection兰州大学
物理科学与技术学院
Corresponding AuthorSun, Sean X.; Li, Rong
Affiliation
1.Center for Cell Dynamics, Department of Cell Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, Baltimore; MD; 21205, United States
2.Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore; MD; 21218, United States
3.Mechanobiology Institute, National University of Singapore, Singapore, Singapore
4.Department of Mechanical Engineering, Kennesaw State University, Marietta; GA; 30060, United States
5.Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore; MD; 21218, United States
6.School of Physical Science and Technology, Lanzhou University, Lanzhou; Gansu; 730000, China
Recommended Citation
GB/T 7714
Wang, HaiYang,Li, Yizeng,Yang, Jing,et al. Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes[J]. Science Advances,2020,6(14).
APA Wang, HaiYang.,Li, Yizeng.,Yang, Jing.,Duan, Xing.,Kalab, Petr.,...&Li, Rong.(2020).Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes.Science Advances,6(14).
MLA Wang, HaiYang,et al."Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes".Science Advances 6.14(2020).
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