兰州大学机构库
Diversity of Antimicrobial Peptides in Three Partially Sympatric Frog Species in Northeast Asia and Implications for Evolution
Wang, Qing1; Xia, Rui1,2; Ji, Jing Jing1,3; Zhu, Qian1,4; Li, Xiao Ping1,3; Ma, Yue1,5; Xu, Yan Chun1,5,6
2020-02
Source PublicationGENES   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
EISSN2073-4425
Volume11Issue:2
page numbers26
AbstractAntimicrobial peptides (AMPs) are evolutionarily ancient molecules that play an essential role in innate immunity across taxa from invertebrates to vertebrates. The evolution system of AMP system has not been well explained in the literature. In this study, we cloned and sequenced AMP transcriptomes of three frog species, namely Rana dybowskii, Rana amurensis, and Pelophylax nigromaculatus, which are partially sympatric in northeast Asia, but show different habitat preferences. We found that each species contained 7 to 14 families of AMPs and the diversity was higher in species with a large geographic range and greater habitat variation. All AMPs are phylogenetically related but not associated with the speciation process. Most AMP genes were under negative selection. We propose that the diversification and addition of novel functions and improvement of antimicrobial efficiency are facilitated by the expansion of family members and numbers. We also documented significant negative correlation of net charges and numbers of amino acid residues between the propiece and mature peptide segments. This supports the Net Charge Balance Hypothesis. We propose the Cut Point Sliding Hypothesis as a novel diversification mechanism to explain the correlation in lengths of the two segments.
Keywordantimicrobial peptides transcriptome diversity frog adaptive evolution
PublisherMDPI
DOI10.3390/genes11020158
Indexed BySCIE
Language英语
Funding ProjectNational Natural Science Foundation of China[31370393]
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000519271500090
PublisherMDPI
Original Document TypeArticle
PMID 32024145
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/416782
Collection兰州大学
生命科学学院
Corresponding AuthorXu, Yan Chun
Affiliation
1.Northeast Forestry Univ, Coll Wildlife & Protected Area, Dept Physiol, Harbin 150040, Peoples R China
2.Lanzhou Univ, Sch Life Sci, Dept Ecol, Lanzhou 730000, Peoples R China
3.BGI Shenzhen, Shenzhen 518083, Peoples R China
4.Beijing E Young Technol Co Ltd, Beijing 100021, Peoples R China
5.State Forestry & Grassland Adm, Detecting Ctr Wildlife, Harbin 150040, Peoples R China
6.State Forestry & Grassland Adm, Res Ctr Engn Technol Wildlife Conservat & Utiliza, Harbin 150040, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qing,Xia, Rui,Ji, Jing Jing,et al. Diversity of Antimicrobial Peptides in Three Partially Sympatric Frog Species in Northeast Asia and Implications for Evolution[J]. GENES,2020,11(2).
APA Wang, Qing.,Xia, Rui.,Ji, Jing Jing.,Zhu, Qian.,Li, Xiao Ping.,...&Xu, Yan Chun.(2020).Diversity of Antimicrobial Peptides in Three Partially Sympatric Frog Species in Northeast Asia and Implications for Evolution.GENES,11(2).
MLA Wang, Qing,et al."Diversity of Antimicrobial Peptides in Three Partially Sympatric Frog Species in Northeast Asia and Implications for Evolution".GENES 11.2(2020).
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