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Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis
Guo, Lanlan1; Ma, Jing2; Tang, Jia3; Hu, Dingyao4; Zhang, Wei5; Zhao, Xue6
2019-11-04
Source PublicationJournal of Diabetes Research   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN2314-6745
EISSN2314-6753
Volume2019
page numbers29
AbstractTo compare the efficacy and safety of metformin, glyburide, and insulin in treating gestational diabetes mellitus (GDM), a meta-analysis of randomized controlled trials (RCTs) was conducted. PubMed, Embase, CINAHL, Web of Science, and Cochrane Library to November 13, 2018, were searched for RCT adjusted estimates of the efficacy and safety of metformin, glyburide, and insulin treatments in GDM patients. There were 41 studies involving 7703 GDM patients which were included in this meta-analysis; 12 primary outcomes and 24 secondary outcomes were detected and analyzed. Compared with metformin, insulin had a significant increase in the risk of preeclampsia (RR, 0.57; 95% CI, 0.45 to 0.72; P<0.001), NICU admission (RR, 0.75; 95% CI, 0.64 to 0.87; P<0.001), neonatal hypoglycemia (RR, 0.57; 95% CI, 0.49 to 0.66; P<0.001), and macrosomia (RR, 0.68; 95% CI, 0.55 to 0.86; P<0.05). To the outcomes of birth weight and gestational age at delivery, insulin had a significant increase when compared with metformin (MD, 114.48; 95% CI, 37.32 to 191.64; P<0.01; MD, 0.23; 95% CI, 0.12 to 0.34; P<0.001; respectively). Of the two groups between glyburide and metformin, metformin had lower gestational weight gain compared with glyburide (MD, 1.67; 95% CI, 0.26 to 3.07; P<0.05). Glyburide had a higher risk of neonatal hypoglycemia compared with insulin (RR, 1.76; 95% CI, 1.32 to 2.36; P<0.001). This meta-analysis found that metformin could be a safe and effective treatment for GDM. However, clinicians should pay attention on the long-term offspring outcomes of the relative data with GDM patients treated with metformin. Compared with insulin, glyburide had a higher increase of neonatal hypoglycemia. The use of glyburide in pregnancy for GDM women appears to be unclear.
PublisherHINDAWI LTD
DOI10.1155/2019/9804708
Indexed BySCIE
Language英语
WOS Research AreaEndocrinology & Metabolism ; Research & Experimental Medicine
WOS SubjectEndocrinology & Metabolism ; Medicine, Research & Experimental
WOS IDWOS:000498548600002
PublisherHINDAWI LTD
Original Document TypeReview
PMID 3178167
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/416831
Collection兰州大学
第二临床医学院
Corresponding AuthorMa, Jing
Affiliation
1.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Dept Radiat Oncol,Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China
2.Gansu Prov Hosp, Dept Endocrinol & Metab, Lanzhou 730000, Gansu, Peoples R China
3.Fudan Univ, Huashan Hosp, Dept Infect Dis, Shanghai 200041, Peoples R China
4.Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Gansu, Peoples R China
5.Zunyi Med Coll, Affiliated Hosp, Dept Crit Care Med, Zunyi 563000, Guizhou, Peoples R China
6.Shandong Univ, Shandong Prov Hosp, Dept Nephrol, Jinan 250021, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Guo, Lanlan,Ma, Jing,Tang, Jia,et al. Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis[J]. Journal of Diabetes Research,2019,2019.
APA Guo, Lanlan,Ma, Jing,Tang, Jia,Hu, Dingyao,Zhang, Wei,&Zhao, Xue.(2019).Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis.Journal of Diabetes Research,2019.
MLA Guo, Lanlan,et al."Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis".Journal of Diabetes Research 2019(2019).
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