兰州大学机构库 >化学化工学院
Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death
Liu Bin1; Cui Liusu2; Zhou, B(周波)3; Zhang Lingling1; Liu Zhihui1; Zhang Lu1
2019
Source PublicationACTA PHARMACOLOGICA SINICA   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN1671-4083
EISSN1745-7254
Volume40Issue:11Pages:1412-1423
page numbers12
AbstractExcessive and abnormal vessel growth plays a critical role in the pathogenesis of many diseases, such as cancer.Angiogenesis is one of the hallmarks of cancer growth, invasion, and metastasis.Discovery of novel antiangiogenic agents would provide new insights into the mechanisms of angiogenesis, as well as potential drugs for cancer treatment.In the present study, we investigated the antiangiogenic activity of a series of monocarbonyl analogs of curcumin synthesized previously in our lab.We found that curcumin analog A2 displayed the full potential to be developed as a novel antiangiogenic agent.Curcumin analog A2 at and above 20 muM dramatically inhibited the migration and tube formation of human umbilical vein endothelial cells(HUVECs)in vitro, new microvessels sprouting from the rat aortic rings ex vivo and newly formed microvessels in chicken chorioallantoic membranes(CAMs)and Matrigel plus in vivo.We further demonstrated that curcumin analog A2 exerted its antiangiogenic activity mainly through inducing endothelial cell death via elevating NADH/NADPH oxidase-derived ROS.Curcumin analog A2 at the antiangiogenic concentrations also triggered autophagy in HUVECs, but this process is neither a pre-requisite for toxicity, leading to the cell death nor a protective response against the toxicity of curcumin analog A2.In conclusion, we demonstrate for the first time the potent antiangiogenic activity of the monocarbonyl curcumin analog A2, which could serve as a promising potential therapeutic agent for the prevention and treatment angiogenesis-related diseases, such as cancer.
Keywordmonocarbonyl curcumin analog angiogenesis apoptosis autophagy necroptosis reactive oxygen species vascular endothelial cell bafilomycin A1 wortmannin
PublisherNATURE PUBLISHING GROUP
DOI10.1038/s41401-019-0224-x
Indexed BySCIE ; CSCD
Language英语
WOS Research AreaGeneral & Internal Medicine
WOS SubjectMEDICINE GENERAL INTERNAL
WOS IDWOS:000494974700005
CSCD IDCSCD:6609381
Original Document TypeArticle
PMID 3100077
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/417561
Collection化学化工学院
兰州大学
Affiliation
1.College of Bioengineering, Henan University of Technology, Zhengzhou, Henan 450001, China
2.Morphological laboratory, Xinxiang Medical University, Xinxiang, Henan 453003, China
3.Lanzhou University, State Key Laboratory of Applied Organic Chemistry, Lanzhou, Gansu 730000, China
Recommended Citation
GB/T 7714
Liu Bin,Cui Liusu,Zhou Bo,et al. Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death[J]. ACTA PHARMACOLOGICA SINICA,2019,40(11):1412-1423.
APA Liu Bin,Cui Liusu,Zhou Bo,Zhang Lingling,Liu Zhihui,&Zhang Lu.(2019).Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death.ACTA PHARMACOLOGICA SINICA,40(11),1412-1423.
MLA Liu Bin,et al."Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death".ACTA PHARMACOLOGICA SINICA 40.11(2019):1412-1423.
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