兰州大学机构库
Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow
Li, Long1,2; Kang, Wei1; Wang, Jizeng1
2020-01-02
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
EISSN1422-0067
Volume21Issue:2
page numbers16
AbstractCatch bond, whose lifetime increases with applied tensile force, can often mediate rolling adhesion of cells in a hydrodynamic environment. However, the mechanical mechanism governing the kinetics of rolling adhesion of cells through catch-bond under shear flow is not yet clear. In this study, a mechanical model is proposed for catch-bond-mediated cell adhesion in shear flow. The stochastic reaction of bond formation and dissociation is described as a Markovian process, whereas the dynamic motion of cells follows classical analytical mechanics. The steady state of cells significantly depends on the shear rate of flow. The upper and lower critical shear rates required for cell detachment and attachment are extracted, respectively. When the shear rate increases from the lower threshold to the upper threshold, cell rolling became slower and more regular, implying the flow-enhanced adhesion phenomenon. Our results suggest that this flow-enhanced stability of rolling adhesion is attributed to the competition between stochastic reactions of bonds and dynamics of cell rolling, instead of force lengthening the lifetime of catch bonds, thereby challenging the current view in understanding the mechanism behind this flow-enhanced adhesion phenomenon. Moreover, the loading history of flow defining bistability of cell adhesion in shear flow is predicted. These theoretical predictions are verified by Monte Carlo simulations and are related to the experimental observations reported in literature.
Keywordcatch bond rolling adhesion Markovian process shear rate flow-enhanced adhesion bistability
PublisherMDPI
DOI10.3390/ijms21020584
Indexed BySCIE
Language英语
Funding ProjectNational Natural Science Foundation of China[11925204][11602099] ; China Scholarship Council (CSC)[201806185038] ; 111 Project[B14044]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000515380000214
PublisherMDPI
Original Document TypeArticle
PMID 31963253
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/418128
Collection兰州大学
Corresponding AuthorLi, Long; Wang, Jizeng
Affiliation
1.Lanzhou Univ, Key Lab Mech Disaster & Environm Western China, Minist Educ, Coll Civil Engn & Mech, Lanzhou 730000, Peoples R China
2.FAU Erlangen Nurnberg, Inst Theoret Phys, PULS Grp, D-91058 Erlangen, Germany
Recommended Citation
GB/T 7714
Li, Long,Kang, Wei,Wang, Jizeng. Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(2).
APA Li, Long,Kang, Wei,&Wang, Jizeng.(2020).Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(2).
MLA Li, Long,et al."Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.2(2020).
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