兰州大学机构库 >物理科学与技术学院
Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation
Wu, JH(吴锦华); Du, Shanshan; Wang, YH(王育华)
2019
Source PublicationJournal of Materials Chemistry B   Impact Factor & Quartile
ISSN20507518
EISSN2050-7518
Volume7Issue:46Pages:7306-7313
page numbers8
AbstractRare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT). NaGd(MoO4)2-based materials have a scheelite structure with good thermal and chemical stability, and excellent up-conversion luminescence properties after co-doping rare earth ions (Tm3+ and Yb3+), which can effectively excite the photosensitizer to generate reactive oxygen species (ROS). In this work, Tm3+ and Yb3+ co-doped NaGd(MoO4)2 upconversion nanoparticles (UCNPs) are prepared by the sol-gel method and further complexed with photosensitizer MC540 (UCNPs@MC540). The prepared UCNPs showed a tetragonal phase and revealed nanoparticles with an average size of 150 nm. Under 980 nm excitation, the UCNPs exhibited a dominant blue emission band (1G43H6) of Tm3+, while the optimum doping concentration was identified at 1% Tm3+ and 20% Yb3+. In addition, the blue emissions of Tm3+ simultaneously activate the MC540 composited on the surface of the nanoparticles to produce a large amount of singlet oxygen (1O2), which is detected by DCFH-DA. Moreover, UCNPs@MC540 also shows strong emission at around 800 nm near-infrared. The results show that the UCNPs@MC540 materials have potential application prospects in PDT and biological imaging.
© 2019 The Royal Society of Chemistry.
PublisherROYAL SOC CHEMISTRY
DOI10.1039/c9tb01629e
Indexed BySCIE ; EI
Language英语
Funding ProjectNational Natural Science Foundation of China[51672115] ; Development and Reform Commission of Hunan Province[] ; Fundamental Research Funds for the Central Universities[]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000499487400003
PublisherRoyal Society of Chemistry
EI Accession Number20194907785118
EI KeywordsChemical stability ; Gadolinium compounds ; Luminescence of inorganic solids ; Metal ions ; Nanoparticles ; Oxygen ; Photodynamic therapy ; Photosensitizers ; Rare earths ; Sodium compounds ; Sol-gel process ; Sol-gels ; Tungstate minerals ; Ytterbium compounds
EI Classification NumberMedicine and Pharmacology:461.6 ; Minerals:482.2 ; Metallurgy:531.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Chemistry:801 ; Chemical Products Generally:804 ; Inorganic Compounds:804.2 ; Glass:812.3 ; Solid State Physics:933
Original Document TypeJournal article (JA)
PMID 31670352
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/418395
Collection物理科学与技术学院
兰州大学
Corresponding AuthorWang, Yuhua
Affiliation
Department of Materials Science, School of Physical Science and Technology, Key Laboratory of Special Function Materials and Structure Design of Ministry of Education, Lanzhou University, Lanzhou; 730000, China
First Author AffilicationSchool of Physical Science and Technology
Corresponding Author AffilicationSchool of Physical Science and Technology
Recommended Citation
GB/T 7714
Wu, Jinhua,Du, Shanshan,Wang, Yuhua. Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation[J]. Journal of Materials Chemistry B,2019,7(46):7306-7313.
APA Wu, Jinhua,Du, Shanshan,&Wang, Yuhua.(2019).Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation.Journal of Materials Chemistry B,7(46),7306-7313.
MLA Wu, Jinhua,et al."Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation".Journal of Materials Chemistry B 7.46(2019):7306-7313.
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