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Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics
Cao, Jinlong1,2; Yang, Xin3; Li, Jianpeng1,2; Wu, Hao1,2; Li, Pan1,2; Yao, Zhiqiang1,2; Dong, Zhichun1,2; Tian, Junqiang2
2020-01-15
Source PublicationFrontiers in Oncology   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN2234-943X
Volume9
page numbers14
AbstractBladder cancer is the most common cancer of the urinary system and its treatment has scarcely progressed for nearly 30 years. Advances in checkpoint inhibitor research have seemingly provided a new approach for treatment. However, there have been issues predicting immunotherapeutic biomarkers and identifying new therapeutic targets. We downloaded the gene expression profile and clinical data of 408 cases bladder urinary cancer from the Cancer Genome Atlas (TCGA) portal, and the abundance ratio of immune cells for each sample was obtained via the "Cell Type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT)" algorithm. Then, four survival-related immune cells were obtained via Kaplan-Meier survival analysis, and 933 immune-related genes were obtained via a variance analysis. Enrichment, protein-protein interaction, and co-expression analyses were performed for these genes. Lastly, 4 survival-related immune cells and 24 hub genes were identified, four of which were related to overall survival. More importantly, these immune cells and genes were closely related to the clinical features. These cells and genes may have research value and clinical application in bladder cancer immunotherapy. Our study not only provides cell and gene targets for bladder cancer immunotherapy, but also provides new ideas for researchers to explore the immunotherapy of various tumors.
Keywordbladder urinary cancer immunotherapy tumor microenvironment TCGA bioinformatics
PublisherFRONTIERS MEDIA SA
DOI10.3389/fonc.2019.01533
Indexed BySCIE
Language英语
Funding ProjectFundamental Research Funds for the Central Universities[561219007] ; Doctoral Research Foundation of Lanzhou University Second Hospital[ynbskyjj2015-2-7] ; Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital[CY2017-BJ16] ; Cuiying Graduate Supervisor Applicant Training Program of Lanzhou University Second Hospital[201704] ; Industry Planning Project of Health Department of Gansu Province[GWGL2013-30] ; Science and Technology Project of Chengguan District, Lanzhou City, Gansu Province Science and Technology Bureau[2017KJGG0052]
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000509904700001
PublisherFRONTIERS MEDIA SA
Original Document TypeArticle
PMID 32010623
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/418604
Collection兰州大学
第二临床医学院
Corresponding AuthorTian, Junqiang
Affiliation
1.Lanzhou Univ, Hosp 2, Dept Urol, Lanzhou, Peoples R China
2.Key Lab Urol Dis Gansu Prov, Lanzhou, Peoples R China
3.Lanzhou Univ, Hosp 2, Reprod Med Ctr, Lanzhou, Peoples R China
First Author AffilicationSecond Clinical School
First Signature AffilicationSecond Clinical School
Recommended Citation
GB/T 7714
Cao, Jinlong,Yang, Xin,Li, Jianpeng,et al. Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics[J]. Frontiers in Oncology,2020,9.
APA Cao, Jinlong.,Yang, Xin.,Li, Jianpeng.,Wu, Hao.,Li, Pan.,...&Tian, Junqiang.(2020).Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics.Frontiers in Oncology,9.
MLA Cao, Jinlong,et al."Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics".Frontiers in Oncology 9(2020).
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