兰州大学机构库
Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome
Khan, Israr1,2,3; Ullah, Naeem1,2,3; Zha, Lajia1,2,3; Bai, Yanrui1,2,3; Khan, Ashiq1,4; Zhao, Tang1,2,3; Che, Tuanjie5; Zhang, CJ(张春江)1,2,3,5
2019-09
Source PublicationPATHOGENS   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
EISSN2076-0817
Volume8Issue:3
page numbers28
AbstractInflammatory bowel disease (IBD) is a chronic complex inflammatory gut pathological condition, examples of which include Crohn's disease (CD) and ulcerative colitis (UC), which is associated with significant morbidity. Although the etiology of IBD is unknown, gut microbiota alteration (dysbiosis) is considered a novel factor involved in the pathogenesis of IBD. The gut microbiota acts as a metabolic organ and contributes to human health by performing various physiological functions; deviation in the gut flora composition is involved in various disease pathologies, including IBD. This review aims to summarize the current knowledge of gut microbiota alteration in IBD and how this contributes to intestinal inflammation, as well as explore the potential role of gut microbiota-based treatment approaches for the prevention and treatment of IBD. The current literature has clearly demonstrated a perturbation of the gut microbiota in IBD patients and mice colitis models, but a clear causal link of cause and effect has not yet been presented. In addition, gut microbiota-based therapeutic approaches have also shown good evidence of their effects in the amelioration of colitis in animal models (mice) and IBD patients, which indicates that gut flora might be a new promising therapeutic target for the treatment of IBD. However, insufficient data and confusing results from previous studies have led to a failure to define a core microbiome associated with IBD and the hidden mechanism of pathogenesis, which suggests that well-designed randomized control trials and mouse models are required for further research. In addition, a better understanding of this ecosystem will also determine the role of prebiotics and probiotics as therapeutic agents in the management of IBD.
Keywordinflammatory bowel disease gut microbiota pathogenesis prebiotics probiotics synbiotics fecal microbiota transplantation (FMT)
PublisherMDPI
DOI10.3390/pathogens8030126
Indexed BySCIE
Language英语
Funding ProjectJiangsu Science and Technology Major Project[BA2016036] ; Lanzhou Science and Technology Funds[2015-3-81] ; Gansu Science and Technology Major Project[17ZD2FA009]
WOS Research AreaMicrobiology
WOS SubjectMicrobiology
WOS IDWOS:000488003600061
PublisherMDPI
Original Document TypeReview
PMID 31412603
ESI Hot Paper2021-09
ESI Hicited Paper2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-05 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03
Citation statistics
Cited Times:399[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/419160
Collection兰州大学
生命科学学院
Corresponding AuthorZhang, Chunjiang
Affiliation
1.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China
2.Lanzhou Univ, Minist Educ, Key Lab Cell Act & Stress Adaptat, Lanzhou 730000, Gansu, Peoples R China
3.Lanzhou Univ, Gansu Key Lab Biomonitoring & Bioremediat Environ, Lanzhou 730000, Peoples R China
4.Lanzhou Univ, Probiot & Biol Feed Res Ctr, Lanzhou 730000, Gansu, Peoples R China
5.Gansu Key Lab Funct Genom & Mol Diag, Lanzhou 730000, Gansu, Peoples R China
First Author AffilicationSchool of Life Sciences
Corresponding Author AffilicationSchool of Life Sciences
First Signature AffilicationSchool of Life Sciences
Recommended Citation
GB/T 7714
Khan, Israr,Ullah, Naeem,Zha, Lajia,et al. Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome[J]. PATHOGENS,2019,8(3).
APA Khan, Israr.,Ullah, Naeem.,Zha, Lajia.,Bai, Yanrui.,Khan, Ashiq.,...&Zhang, Chunjiang.(2019).Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome.PATHOGENS,8(3).
MLA Khan, Israr,et al."Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome".PATHOGENS 8.3(2019).
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