兰州大学机构库
Reactions Related to CAR-T Cell Therapy
Miao, Lele1,2; Zhang, Zhengchao1,2; Ren, Zhijian1,2; Li, Yumin1,2
2021-04-28
Source PublicationFrontiers in Immunology   Impact Factor & Quartile
ISSN1664-3224
Volume12
page numbers14
AbstractThe application of chimeric antigen receptor (CAR) T-cell therapy as a tumor immunotherapy has received great interest in recent years. This therapeutic approach has been used to treat hematological malignancies solid tumors. However, it is associated with adverse reactions such as, cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), off-target effects, anaphylaxis, infections associated with CAR-T-cell infusion (CTI), tumor lysis syndrome (TLS), B-cell dysplasia, hemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome (MAS) and coagulation disorders. These adverse reactions can be life-threatening, and thus they should be identified early and treated effectively. In this paper, we review the adverse reactions associated with CAR-T cells, the mechanisms driving such adverse reactions, and strategies to subvert them. This review will provide important reference data to guide clinical application of CAR-T cell therapy.
Keywordchimeric antigen receptor T cellimmunotherapyadverse reactionsmechanismcoping strategies
PublisherFRONTIERS MEDIA SA
DOI10.3389/fimmu.2021.663201
Indexed BySCOPUS ; SCIE
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000649279900001
Original Document TypeReview
PMID 33995389
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/450180
Collection兰州大学
第二临床医学院
Corresponding AuthorLi, Yumin
Affiliation
1.Lanzhou Univ, Hosp 2, Dept Gen Surg, Lanzhou, Peoples R China;
2.Lanzhou Univ, Hosp 2, Key Lab Digest Syst Tumors Gansu Prov, Lanzhou, Peoples R China
First Author AffilicationSecond Clinical School
Corresponding Author AffilicationSecond Clinical School
Recommended Citation
GB/T 7714
Miao, Lele,Zhang, Zhengchao,Ren, Zhijian,et al. Reactions Related to CAR-T Cell Therapy[J]. Frontiers in Immunology,2021,12.
APA Miao, Lele,Zhang, Zhengchao,Ren, Zhijian,&Li, Yumin.(2021).Reactions Related to CAR-T Cell Therapy.Frontiers in Immunology,12.
MLA Miao, Lele,et al."Reactions Related to CAR-T Cell Therapy".Frontiers in Immunology 12(2021).
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