| Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance | |
| Zhong, Chao1,2; Zhang, Fangyan2; Yao, Jia4; Zhu, Yuewen2; Zhu, Ningyi2; Zhang, Yun2; Liu, Hui2; Gou, Sanhu2; Ni, Jingman1,2,3 | |
| 2021-04 | |
| Online publication date | 2021-03 |
| Source Publication | BIOCHEMICAL PHARMACOLOGY Impact Factor & Quartile |
| ISSN | 0006-2952 |
| EISSN | 1873-2968 |
| Volume | 186 |
| page numbers | 25 |
| Abstract | In response to the dramatically increasing antimicrobial resistance, a series of new symmetric peptides were designed and synthesized in this study by a ?WWW? motif as the symmetric center, arginine as the positive charge amino acid and the terminus symmetrically tagged with hydrophobic amino acids. Amongst the new symmetric peptide FRRW (FRRWWWRRF-NH2) presented the highest cell selectivity for bacteria over mammalian cell and exerted excellent antimicrobial potential against a broad of bacteria, especially difficult-tokill multidrug-resistant strains clinical isolates. FRRW also displayed perfect stability in physiological salt ions and rapid killing speed as well as acted on multiple mechanisms including non-receptor mediated membrane and intra-molecular mechanisms. Importantly, FRRW emerged a low tendency of resistance in contrast to traditional antibiotics ciprofloxacin and gentamicin. What?s more, FRRW could resist or alleviate or even reverse the ciprofloxacin- and gentamicin-resistance by changing the permeability of bacterial membrane and inhibiting the efflux pumps of bacteria. Furthermore, FRRW exhibited remarkable effectiveness and higher safety in vivo than polymyxin B. In summary, the new symmetric peptide FRRW was promised to be as a new antimicrobial candidate for overcoming the increasing bacterial resistance. |
| Keyword | Antimicrobial peptidesAntimicrobial activityAnti-resistanceMultidrug-resistant bacteriaBiocompatibilityMultiple mechanisms |
| Publisher | PERGAMON-ELSEVIER SCIENCE LTD |
| DOI | 10.1016/j.bcp.2021.114470 |
| Indexed By | SCOPUS ; SCIE |
| Language | 英语 |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Pharmacology & Pharmacy |
| WOS ID | WOS:000640414700001 |
| Original Document Type | Article |
| PMID | 33610592 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/450387 |
| Collection | 兰州大学 |
| Corresponding Author | Ni, Jingman |
| Affiliation | 1.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China; 2.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China; 3.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macao, Peoples R China; 4.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Zhong, Chao,Zhang, Fangyan,Yao, Jia,et al. Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance[J]. BIOCHEMICAL PHARMACOLOGY,2021,186. |
| APA | Zhong, Chao.,Zhang, Fangyan.,Yao, Jia.,Zhu, Yuewen.,Zhu, Ningyi.,...&Ni, Jingman.(2021).Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance.BIOCHEMICAL PHARMACOLOGY,186. |
| MLA | Zhong, Chao,et al."Antimicrobial peptides with symmetric structures against multidrug-resistant bacteria while alleviating antimicrobial resistance".BIOCHEMICAL PHARMACOLOGY 186(2021). |
| Files in This Item: | There are no files associated with this item. | ||||
