兰州大学机构库
5-HT6R null mutatrion induces synaptic and cognitive defects
Sun, Zehui1; Wang, Bingjie1; Chen, Chen3; Li, Chenjian1; Zhang, Yan1,2
2021-05
Online publication date2021-05
Source PublicationAGING CELL   Impact Factor & Quartile
ISSN1474-9718
EISSN1474-9726
Volume20Issue:6
page numbers18
AbstractSerotonin 6 receptor (5-HT6R) is a promising target for a variety of human diseases, such as Alzheimer's disease (AD) and schizophrenia. However, the detailed mechanism underlying 5-HT6R activity in the central nervous system (CNS) is not fully understood. In the present study, 5-HT6R null mutant (5-HT6R(-/-)) mice were found to exhibit cognitive deficiencies and abnormal anxiety levels. 5-HT6R is considered to be specifically localized on the primary cilia. We found that the loss of 5-HT6R affected the Sonic Hedgehog signaling pathway in the primary cilia. 5-HT6R(-/-) mice showed remarkable alterations in neuronal morphology, including dendrite complexity and axon initial segment morphology. Neurons lacking 5-HT6R exhibited increased neuronal excitability. Our findings highlight the complexity of 5-HT6R functions in the primary ciliary and neuronal physiology, supporting the theory that this receptor modulates neuronal morphology and transmission, and contributes to cognitive deficits in a variety of human diseases, such as AD, schizophrenia, and ciliopathies.
Keyword5‐HT6Rlearning and memoryneuronal excitabilityprimary cilia
PublisherWILEY
DOI10.1111/acel.13369
Indexed BySCOPUS ; SCIE
Language英语
WOS Research AreaCell BiologyGeriatrics & Gerontology
WOS SubjectCell BiologyGeriatrics & Gerontology
WOS IDWOS:000647851400001
Original Document TypeArticleEarly Access
PMID 33960602
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/450926
Collection兰州大学
Corresponding AuthorZhang, Yan
Affiliation
1.Peking Univ, Coll Life Sci, State Key Lab Membrane Biol, Room 412, Beijing 100871, Peoples R China;
2.PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China;
3.Lanzhou Univ, Sch Life Sci, Lanzhou, Peoples R China
Recommended Citation
GB/T 7714
Sun, Zehui,Wang, Bingjie,Chen, Chen,et al. 5-HT6R null mutatrion induces synaptic and cognitive defects[J]. AGING CELL,2021,20(6).
APA Sun, Zehui,Wang, Bingjie,Chen, Chen,Li, Chenjian,&Zhang, Yan.(2021).5-HT6R null mutatrion induces synaptic and cognitive defects.AGING CELL,20(6).
MLA Sun, Zehui,et al."5-HT6R null mutatrion induces synaptic and cognitive defects".AGING CELL 20.6(2021).
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