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Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal
Gou, Sanhu1,2; Li, Beibei1; Ouyang, Xu1; Ba, Zufang1; Zhong, Chao1,3; Ni, Jingman1,3
2021-08-24
Online publication date2021-08
Source PublicationACS Omega   Impact Factor & Quartile
ISSN2470-1343
Volume6Issue:33Pages:21359-21367
page numbers9
AbstractDendrimeric antimicrobial peptides or lipopeptides have strong transmembrane ability and antibacterial activity. To obtain some ideal antimicrobial peptides, anoplin, a natural antimicrobial peptide with weak antimicrobial activity, was modified by C-terminal dendrimerization using lysine and N-terminal lipidation using fatty acids. 2K-3A-C4, a trimer of anoplin, was dendrimerized by two lysines at the C-terminal and was lipidated by n-butyric acid at the N-terminal, and thus exhibited the best antibacterial activity. However, the trimer had high hemolytic activity. Finally, A-C8, a simple structural lipopeptide, which is not a dendrimer, was obtained following the lipidation of anoplin using octanoic acid; it exhibited the highest therapeutic index, which makes it a probable antibiotic and thus was screened out.
PublisherAMER CHEMICAL SOC
DOI10.1021/acsomega.1c01854
Indexed BySCOPUS ; SCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000691300900016
Original Document TypeArticle
PMID 3447174
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/471020
Collection兰州大学
Corresponding AuthorNi, Jingman
Affiliation
1.Lanzhou Univ, Sch Pharm, Inst Pharmaceut, Lanzhou 730000, Peoples R China;
2.Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China;
3.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Gou, Sanhu,Li, Beibei,Ouyang, Xu,et al. Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal[J]. ACS Omega,2021,6(33):21359-21367.
APA Gou, Sanhu,Li, Beibei,Ouyang, Xu,Ba, Zufang,Zhong, Chao,&Ni, Jingman.(2021).Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal.ACS Omega,6(33),21359-21367.
MLA Gou, Sanhu,et al."Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal".ACS Omega 6.33(2021):21359-21367.
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