| Construction of Self-Activated Nanoreactors for Cascade Catalytic Anti-Biofilm Therapy Based on H2O2 Self-Generation and Switch-On NO Release | |
| Shi, Yuting1; Cao, Yufei1; Cheng, Ju1,2; Yu, Wenwen3; Liu, Mingsheng1; Yin, Juanjuan1; Huang, Congshu1; Liang, Xiaoqin4; Zhou, Haicun3; Liu, Hongbin3; Yang, Zheng1; Fang, Yu1; Wei, Hua1; Zhao, Guanghui1 | |
| 2022-05-01 | |
| Source Publication | ADVANCED FUNCTIONAL MATERIALS Impact Factor & Quartile |
| ISSN | 1616-301X |
| Volume | 32Issue:20 |
| Abstract | The traditional treatment for bacterial infections is the use of antibiotics, but the overuse of antibiotics can lead to the formation of multidrug-resistant bacteria, and eventually lead to the formation of biofilms, which can resist the attack of the host immune system and the penetration of antibiotics in biofilms. Although biofilm-targeted and stimulus-responsive antibiotic delivery nanocarriers are available, the drugs that can be delivered is extremely limited. Therefore, an amphiphilic supramolecule Arg-CD-AcMH is constructed via host-guest interactions between beta-CD-terminated arginine (Arg-CD) and ferrocene-terminated acetal-modified maltoheptaose. The amphiphilic supramolecule Arg-CD-AcMH can self-assemble with glucoamylase and glucose oxidase in aqueous solution to form spherical nanoparticles through hydrophilic-hydrophobic and electrostatic interactions. These nanoparticles can respond to the micro-environment in the biofilm and selectively increase the level of H2O2 in the biofilm through the cascading catalytic effect of enzymes based on the self-supply glucose, thus providing conditions for the release of anti-biofilm active drug nitric oxide. |
| Keyword | anti-biofilm cascade nanoreactor nitric oxide self-activated Amino acids Antibiotics Biofilms Controlled drug delivery Glucose Glucose oxidase Glucose sensors Iron compounds Nanoparticles Nanoreactors Organometallics Targeted drug delivery Amphiphilics Antibiofilms Bacterial infections Cascade Multidrug resistants NO release Self-activated Self-generation Supramolecules Switch-on |
| Publisher | WILEY-V C H VERLAG GMBH |
| DOI | 10.1002/adfm.202111148 |
| Indexed By | SCIE ; EI |
| Language | 英语 |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| WOS ID | WOS:000753320800001 |
| EI Accession Number | 20220711647071 |
| EI Keywords | Nitric oxide |
| EI Classification Number | 461.6 Medicine and Pharmacology ; 461.9 Biology ; 462.1 Biomedical Equipment, General ; 462.5 Biomaterials (including synthetics) ; 761 Nanotechnology ; 804.1 Organic Compounds ; 804.2 Inorganic Compounds ; 933 Solid State Physics |
| Original Document Type | Article ; Early Access ; Journal article (JA) |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/476046 |
| Collection | 兰州大学 |
| Affiliation | 1.Lanzhou Univ, Coll Chem & Chem Engn, Inst Biochem Engn & Environm Technol, State Key Lab Appl Organ Chem, 222 Tianshui Rd, Lanzhou 730000, Peoples R China; 2.Lanzhou Univ, Sch Basic Med Sci, 222 Tianshui Rd, Lanzhou 730000, Peoples R China; 3.Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China; 4.Gansu Prov Peoples Hosp, Dept Pathol, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Shi, Yuting,Cao, Yufei,Cheng, Ju,et al. Construction of Self-Activated Nanoreactors for Cascade Catalytic Anti-Biofilm Therapy Based on H2O2 Self-Generation and Switch-On NO Release[J]. ADVANCED FUNCTIONAL MATERIALS,2022,32(20). |
| APA | Shi, Yuting.,Cao, Yufei.,Cheng, Ju.,Yu, Wenwen.,Liu, Mingsheng.,...&Zhao, Guanghui.(2022).Construction of Self-Activated Nanoreactors for Cascade Catalytic Anti-Biofilm Therapy Based on H2O2 Self-Generation and Switch-On NO Release.ADVANCED FUNCTIONAL MATERIALS,32(20). |
| MLA | Shi, Yuting,et al."Construction of Self-Activated Nanoreactors for Cascade Catalytic Anti-Biofilm Therapy Based on H2O2 Self-Generation and Switch-On NO Release".ADVANCED FUNCTIONAL MATERIALS 32.20(2022). |
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