| Design, Synthesis, and Antimicrobial Activity of Quindoline Derivatives Inspired by the Cryptolepine Alkaloid | |
Chu, Qing-Ru1; He, Ying-Hui1; Tang, Chen1; Zhang, ZJ(张智军)1 ; Luo, Xiong-Fei1; Zhang, Bao-Qi1; Zhou, Yong1; Wu, Tian-Lin1; Du, Sha-Sha1; Yang, Cheng-Jie1; Liu, YQ(刘映前)1,2 | |
| 2022-03-09 | |
| Source Publication | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Impact Factor & Quartile |
| ISSN | 0021-8561 |
| Volume | 70Issue:9Pages:2851-2863 |
| Abstract | Based on the structural characteristics of the cryptolepine alkaloid, a series of new quindoline derivatives bearing various substituents were prepared and evaluated for their fungicidal and antibacterial activities. Bioassay results showed that compound D7 displayed superior in vitro fungicidal activities against Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium graminearum, and Rhizoctonia solani with EC50 values of 0.780, 3.62, 1.59, and 2.85 μg/mL, respectively. Compound A7 showed apparent antibacterial activities toward Xanthomonas oryzae pv. oryzae with a minimum inhibitory concentration (MIC) value of 3.12 μg/mL. Significantly, in vivo antifungal activity suggested that the curative effect (98.3%) of compound D7 was comparable to that of the positive control azoxystrobin (96.7%) at 100 μg/mL. Preliminary mechanistic studies showed that compound D7 might cause mycelial abnormality of S. sclerotiorum, cell membrane breakage, accumulation of reactive oxygen species (ROS), and inhibition of sclerotia formation. Therefore, compound D7 could be a novel broad-spectrum fungicidal candidate against plant fungal diseases. © 2022 American Chemical Society |
| Keyword | Alkaloids Cytology Metabolites Microorganisms Plants (botany) Anti-bacterial activity Anti-microbial activity Cryptolepine Design activity Design synthesis Fungicidal activity Quindoline Sclerotinia Sclerotiorum Structure-activity relationship. Structure-activity relationships quindoline cryptolepine alkaloid antimicrobial activity Sclerotinia sclerotiorum structure-activity relationship |
| Publisher | American Chemical Society |
| DOI | 10.1021/acs.jafc.1c07536 |
| Indexed By | EI ; SCIE |
| Language | 英语 |
| WOS Research Area | Agriculture ; Chemistry ; Food Science & Technology |
| WOS Subject | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| WOS ID | WOS:000767891600007 |
| EI Accession Number | 20221111784484 |
| EI Keywords | Fungicides |
| EI Classification Number | 461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 804 Chemical Products Generally ; 804.1 Organic Compounds |
| Original Document Type | Journal article (JA) ; Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/477926 |
| Collection | 药学院 |
| Corresponding Author | Liu, Ying-Qian |
| Affiliation | 1.School of Pharmacy, Lanzhou University, Lanzhou; 730000, China; 2.State Key Laboratory of Grassland Agro-ecosystems, Lanzhou University, Lanzhou; 730000, China |
| First Author Affilication | School of Pharmacy |
| Corresponding Author Affilication | School of Pharmacy; Lanzhou University |
| Recommended Citation GB/T 7714 | Chu, Qing-Ru,He, Ying-Hui,Tang, Chen,et al. Design, Synthesis, and Antimicrobial Activity of Quindoline Derivatives Inspired by the Cryptolepine Alkaloid[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(9):2851-2863. |
| APA | Chu, Qing-Ru.,He, Ying-Hui.,Tang, Chen.,Zhang, Zhi-Jun.,Luo, Xiong-Fei.,...&Liu, Ying-Qian.(2022).Design, Synthesis, and Antimicrobial Activity of Quindoline Derivatives Inspired by the Cryptolepine Alkaloid.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(9),2851-2863. |
| MLA | Chu, Qing-Ru,et al."Design, Synthesis, and Antimicrobial Activity of Quindoline Derivatives Inspired by the Cryptolepine Alkaloid".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.9(2022):2851-2863. |
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