| Design, Synthesis, and Antifungal Evaluation of Luotonin A Derivatives against Phytopathogenic Fungi | |
| Wang, Ren-Xuan1; Du, Sha-Sha1; Wang, Jing-Ru1; Chu, Qing-Ru1; Tang, Chen1; Zhang, Zhi-Jun1; Yang, Cheng-Jie1; He, Ying-Hui1; Li, Hai-Xing1; Wu, Tian-Lin1; Liu, Ying-Qian1,2 | |
| 2021-12-08 | |
| Source Publication | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Impact Factor & Quartile |
| ISSN | 0021-8561 |
| EISSN | 1520-5118 |
| Volume | 69Issue:48Pages:14467-14477 |
| page numbers | 11 |
| Abstract | Crop diseases caused by fungi threaten food security and exacerbate the food crisis. Inspired by the application of fungicide candidates from natural products in agrochemical discovery, a series of luotonin A derivatives were designed, synthesized, and evaluated for their antifungal activities against five plant fungi. Most of these compounds exhibited significant fungicidal activity against Botrytis cinerea in vitro with EC50 values less than 1 mu g/mL. Among them, compounds w7, w8, w12, and w15 showed superior antifungal activity against B. cinerea with EC50 values of 0.036, 0.050, 0.042, and 0.048 mu g/mL, respectively, which were more potent than boscalid (EC50 = 1.790 mu g/mL). Preliminary mechanism studies revealed that compound w7 might pursue its antifungal activity by disrupting the fungal cell membrane and cell wall. Moreover, in vivo bioassay also indicated that compound w7 could be effective for the control of B. cinerea. The above results evidenced the potential of luotonin A derivatives as novel and promising candidate fungicides. |
| Keyword | luotonin A phytopathogenic fungi Botrytis cinerea antifungal activity mechanism of action |
| Publisher | AMER CHEMICAL SOC |
| DOI | 10.1021/acs.jafc.1c04242 |
| Indexed By | SCIE ; IC |
| Language | 英语 |
| WOS Research Area | Agriculture ; Chemistry ; Food Science & Technology |
| WOS Subject | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| WOS ID | WOS:000750873600011 |
| Original Document Type | Article |
| PMID | 34843231 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/479602 |
| Collection | 兰州大学 |
| Corresponding Author | Zhang, Zhi-Jun; Liu, Ying-Qian |
| Affiliation | 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China; 2.Lanzhou Univ, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Ren-Xuan,Du, Sha-Sha,Wang, Jing-Ru,et al. Design, Synthesis, and Antifungal Evaluation of Luotonin A Derivatives against Phytopathogenic Fungi[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2021,69(48):14467-14477. |
| APA | Wang, Ren-Xuan.,Du, Sha-Sha.,Wang, Jing-Ru.,Chu, Qing-Ru.,Tang, Chen.,...&Liu, Ying-Qian.(2021).Design, Synthesis, and Antifungal Evaluation of Luotonin A Derivatives against Phytopathogenic Fungi.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,69(48),14467-14477. |
| MLA | Wang, Ren-Xuan,et al."Design, Synthesis, and Antifungal Evaluation of Luotonin A Derivatives against Phytopathogenic Fungi".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 69.48(2021):14467-14477. |
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