| Electroconvulsive Therapy-Induced Changes in Functional Brain Network of Major Depressive Disorder Patients: A Longitudinal Resting-State Electroencephalography Study | |
| Sun, Shuting1; Yang, Peng2; Chen, Huayu3; Shao, Xuexiao3; Ji, Shanling3; Li, Xiaowei3,4; Li, Gongying5; Hu, Bin1,6,7,8 | |
| 2022-05-18 | |
| Source Publication | Frontiers in Human Neuroscience Impact Factor & Quartile |
| ISSN | 1662-5161 |
| Volume | 16 |
| page numbers | 13 |
| Abstract | ObjectivesSeveral studies have shown abnormal network topology in patients with major depressive disorder (MDD). However, changes in functional brain networks associated with electroconvulsive therapy (ECT) remission based on electroencephalography (EEG) signals have yet to be investigated. MethodsNineteen-channel resting-state eyes-closed EEG signals were collected from 24 MDD patients pre- and post-ECT treatment. Functional brain networks were constructed by using various coupling methods and binarization techniques. Changes in functional connectivity and network metrics after ECT treatment and relationships between network metrics and clinical symptoms were explored. ResultsECT significantly increased global efficiency, edge betweenness centrality, local efficiency, and mean degree of alpha band after ECT treatment, and an increase in these network metrics had significant correlations with decreased depressive symptoms in repeated measures correlation. In addition, ECT regulated the distribution of hubs in frontal and occipital lobes. ConclusionECT modulated the brain's global and local information-processing patterns. In addition, an ECT-induced increase in network metrics was associated with clinical remission. SignificanceThese findings might present the evidence for us to understand how ECT regulated the topology organization in functional brain networks of clinically remitted depressive patients. |
| Keyword | electroconvulsive therapy electroencephalography major depressive disorder functional connectivity graph theory analysis |
| Publisher | FRONTIERS MEDIA SA |
| DOI | 10.3389/fnhum.2022.852657 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Neurosciences & Neurology ; Psychology |
| WOS Subject | Neurosciences ; Psychology |
| WOS ID | WOS:000806111700001 |
| Original Document Type | Article |
| PMID | 35664348 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/480864 |
| Collection | 兰州大学 |
| Corresponding Author | Li, Xiaowei; Li, Gongying; Hu, Bin |
| Affiliation | 1.Beijing Inst Technol, Sch Med Technol, Brain Hlth Engn Lab, Beijing, Peoples R China; 2.Shandong Daizhuang Hosp, Jining, Peoples R China; 3.Lanzhou Univ, Sch Informat Sci & Engn, Gansu Prov Key Lab Wearable Comp, Lanzhou, Peoples R China; 4.Shandong Acad Intelligent Comp Technol, Jinan, Peoples R China; 5.Huaian Third Peoples Hosp, Dept Psychiat, Huaian, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China; 7.Chinese Acad Sci, Joint Res Ctr Cognit Neurosensor Technol Lanzhou U, Lanzhou, Peoples R China; 8.Lanzhou Univ, Open Source Software & Real Time Syst, Minist Educ, Lanzhou, Peoples R China |
| Recommended Citation GB/T 7714 | Sun, Shuting,Yang, Peng,Chen, Huayu,et al. Electroconvulsive Therapy-Induced Changes in Functional Brain Network of Major Depressive Disorder Patients: A Longitudinal Resting-State Electroencephalography Study[J]. Frontiers in Human Neuroscience,2022,16. |
| APA | Sun, Shuting.,Yang, Peng.,Chen, Huayu.,Shao, Xuexiao.,Ji, Shanling.,...&Hu, Bin.(2022).Electroconvulsive Therapy-Induced Changes in Functional Brain Network of Major Depressive Disorder Patients: A Longitudinal Resting-State Electroencephalography Study.Frontiers in Human Neuroscience,16. |
| MLA | Sun, Shuting,et al."Electroconvulsive Therapy-Induced Changes in Functional Brain Network of Major Depressive Disorder Patients: A Longitudinal Resting-State Electroencephalography Study".Frontiers in Human Neuroscience 16(2022). |
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