兰州大学机构库
Safety and immunogenicity of SARS-CoV-2 vaccines in Chinese patients with cirrhosis: a prospective multicenter study
2022-06-01
Source PublicationHEPATOLOGY INTERNATIONAL
ISSN1936-0533
Volume16Issue:3Pages:691-701
AbstractBackground Data on safety and immunogenicity of coronavirus disease 2019 (COVID-19) vaccination in patients with compensated (C-cirrhosis) and decompensated cirrhosis (D-cirrhosis) are limited. Methods In this prospective multicenter study, adult participants with C-cirrhosis and D-cirrhosis were enrolled and received two doses of inactivated whole-virion COVID-19 vaccines. Adverse events were recorded within 14 days after any dose of vaccination, and serum samples of enrolled patients were collected and tested for SARS-CoV-2 neutralizing antibodies at least 14 days after the second dose. Risk factors for negative neutralizing antibody were analyzed. Results In total, 553 patients were enrolled from 15 centers in China, including 388 and 165 patients with C-cirrhosis and D-cirrhosis. The vaccines were well tolerated, most adverse reactions were mild and transient, and injection site pain (23/388 [5.9%] vs 9/165 [5.5%]) and fatigue (5/388 [1.3%] vs 3/165 [1.8%]) were the most frequently local and systemic adverse events in both the C-cirrhosis and D-cirrhosis groups. Overall, 4.4% (16/363) and 0.3% (1/363) of patients were reported Grades 2 and 3 alanine aminotransferase (ALT) elevations (defined as ALT > 2 upper limit of normal [ULN] but <= 5 ULN, and ALT > 5 ULN, respectively). The positive rates of COVID-19 neutralizing antibodies were 71.6% (278/388) and 66.1% (109/165) in C-cirrhosis and D-cirrhosis groups. Notably, Child-Pugh score of B and C levels was an independent risk factor of negative neutralizing antibody. Conclusions Inactivated COVID-19 vaccinations are safe with acceptable immunogenicity in cirrhotic patients, and Child-Pugh score of B and C levels is associated with hyporesponsive to COVID-19 vaccination.
KeywordChild-Pugh Compensated cirrhosis Coronavirus disease 2019 Decompensated cirrhosis Hepatitis B virus Immunogenicity Safety Severe acute respiratory syndrome coronavirus 2 Vaccine Vaccination
PublisherSPRINGER
DOI10.1007/s12072-022-10332-9
Indexed BySCIE
Language英语
WOS Research AreaGastroenterology & Hepatology
WOS SubjectGastroenterology & Hepatology
WOS IDWOS:000780665500001
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/481070
Collection兰州大学
Affiliation1.Southeast Univ, Zhongda Hosp, Sch Med, Dept Radiol, Nanjing, Jiangsu, Peoples R China;
2.Xingtai Peoples Hosp, CHESS COVID 19 Grp, Xingtai, Hebei, Peoples R China;
3.Fudan Univ, Dept Infect Dis, Huashan Hosp, Shanghai, Peoples R China;
4.Third Cent Hosp Tianjin, Dept Hepatol & Gastroenterol, Tianjin, Peoples R China;
5.Sixth Peoples Hosp Shenyang, CHESS COVID 19 Grp, Shenyang, Liaoning, Peoples R China;
6.Third Peoples Hosp Taiyuan, Dept Hepatol, Taiyuan, Shanxi, Peoples R China;
7.Lishui Peoples Hosp, Dept Infect Dis, Lishui, Zhejiang, Peoples R China;
8.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing, Peoples R China;
9.Peking Univ, Infect Dis Ctr, Sch Basic Med Sci, Hlth Sci Ctr, Beijing, Peoples R China;
10.Lishui Peoples Hosp, Clinal Lab, Lishui, Zhejiang, Peoples R China;
11.Nanjing Univ Chinese Med, Dept Infect Dis, Nanjing Hosp Chinese Med, Nanjing, Jiangsu, Peoples R China;
12.Baoding Peoples Hosp, Dept Gastroenterol, Baoding, Heibei, Peoples R China;
13.Qingdao Univ, Liver Dis Ctr, Div Hepatol, Affiliated Hosp, Qingdao, Shandong, Peoples R China;
14.Dalian Med Univ, Liver Dis Ctr Integrated Tradit Chinese & Western, Dept Infect Dis, Affiliated Hosp 1, Dalian, Liaoning, Peoples R China;
15.Jincheng Peoples Hosp, Dept Hepatobiliary Surg, Jincheng, Shanxi, Peoples R China;
16.Fourth Peoples Hosp Qinghai Prov, Dept Gastroenterol, Xining, Qinghai, Peoples R China;
17.Third Peoples Hosp Linfen City, Dept Liver Dis, Linfen, Shanxi, Peoples R China;
18.Jiangnan Univ, CHESS COVID 19 Grp, Peoples Hosp Wuxi 5, Affiliated Hosp, Wuxi, Jiangsu, Peoples R China;
19.Peoples Hosp Ningxia Hui Autonomous Reg, CHESS COVID 19 Grp, Yinchuan, Ningxia, Peoples R China;
20.Zhejiang Univ, Lishui Hosp, CHESS COVID 19 Grp, Lishui, Zhejiang, Peoples R China;
21.Jiangsu Univ, Dept Hepatol, Zhenjiang Hosp 3, Zhenjiang, Jiangsu, Peoples R China;
22.Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 2, Chongqing, Peoples R China;
23.Third Peoples Hosp Tibet Autonomous Reg, CHESS COVID 19 Grp, Lhasa, Tibet Autonomou, Peoples R China;
24.Lanzhou Univ, Dept Infect Dis, Hosp 1, Lanzhou, Gansu, Peoples R China;
25.Southwest Med Univ, Dept Gastroenterol, Affiliated Hosp, Luzhou, Sichuan, Peoples R China;
26.Zhengzhou Univ, Dept Infect Dis & Hepatol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jitao,Zhang, Qiran,Ai, Jingwen,et al. Safety and immunogenicity of SARS-CoV-2 vaccines in Chinese patients with cirrhosis: a prospective multicenter study[J]. HEPATOLOGY INTERNATIONAL,2022,16(3):691-701.
APA Wang, Jitao.,Zhang, Qiran.,Ai, Jingwen.,Liu, Dengxiang.,Liu, Chuan.,...&Zhang, Wenhong.(2022).Safety and immunogenicity of SARS-CoV-2 vaccines in Chinese patients with cirrhosis: a prospective multicenter study.HEPATOLOGY INTERNATIONAL,16(3),691-701.
MLA Wang, Jitao,et al."Safety and immunogenicity of SARS-CoV-2 vaccines in Chinese patients with cirrhosis: a prospective multicenter study".HEPATOLOGY INTERNATIONAL 16.3(2022):691-701.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Wang, Jitao]'s Articles
[Zhang, Qiran]'s Articles
[Ai, Jingwen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Jitao]'s Articles
[Zhang, Qiran]'s Articles
[Ai, Jingwen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Jitao]'s Articles
[Zhang, Qiran]'s Articles
[Ai, Jingwen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.