| Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Botrytis cinerea Contributes to Disease Control and Fruit Quality Preservation | |
Zhao, Wen-Bin1; An, Jun-Xia1; Hu, Yong-Mei1; Li, An-Ping4; Zhang, Shao-Yong2; Zhang, Bao-Qi1; Zhang, ZJ(张智军)1 ; Luo, Xiong-Fei1; Bian, Qiang3; Ma, Yue1; Ding, Yan-Yan1; Wang, Rui5; Liu, YQ(刘映前)1,2,6 | |
| 2022-10-05 | |
| Source Publication | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Impact Factor & Quartile |
| ISSN | 0021-8561 |
| Volume | 70Issue:39Pages:12297-12309 |
| Abstract | The inhibitory effect of tavaborole on the invasion of Botrytis cinerea in grapes and tomatoes, as well as the potential mechanism involved, was discovered in this study. Our findings showed that tavaborole inhibited Botrytis cinerea spore germination and mycelial expansion in vitro and that the control efficiency in vivo on fruit decay was dose-dependent, which was effective in reducing disease severity and maintaining the organoleptic quality of the fruit, such as reducing weight loss and retaining fruit hardness and titratable acid contents during storage. Furthermore, the precise mechanism of action was investigated further. Propidium iodide staining revealed that Botrytis cinerea treated with tavaborole lost membrane integrity. For further validation, cytoplasmic malondialdehyde accumulation and leakage of cytoplasmic constituents were determined. Notably, the inhibitory effect was also dependent on inhibiting the activities of aminoacyl-tRNA synthetases involved in the aminoacyl-tRNA biosynthesis pathway in Botrytis cinerea. The above findings concluded that tavaborole was effective against Botrytis cinerea infection in postharvest fruit, and a related mechanism was also discussed, which may provide references for the drug repurposing of tavaborole as a postharvest fungicide. © 2022 American Chemical Society. |
| Keyword | Amino acids Biochemistry Biosynthesis Cell proliferation Controlled drug delivery Disease control Quality control Aminoacyl Aminoacyl-tRNA synthetase Biosynthesis pathways Botrytis cinerea Control quality Fruit quality Inhibitory effect Membrane integrity Synthetases Tavaborole |
| Publisher | American Chemical Society |
| DOI | 10.1021/acs.jafc.2c03441 |
| Indexed By | EI |
| Language | 英语 |
| EI Accession Number | 20224012826140 |
| EI Keywords | Fruits |
| EI Classification Number | 461.8 Biotechnology ; 461.9 Biology ; 801.2 Biochemistry ; 802.2 Chemical Reactions ; 804.1 Organic Compounds ; 821.4 Agricultural Products ; 913.3 Quality Assurance and Control |
| Original Document Type | Journal article (JA) |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/486040 |
| Collection | 药学院 |
| Corresponding Author | Bian, Qiang; Liu, Ying-Qian |
| Affiliation | 1.School of Pharmacy, Lanzhou University, Lanzhou; 730000, China; 2.Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou; 313000, China; 3.National Pesticide Engineering Research Center (Tianjin), College of Chemistry, Nankai University, Tianjin; 300071, China; 4.Gansu Institute for Drug Control, Lanzhou; 730000, China; 5.Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province, Weifang University, Weifang; 261061, China; 6.State Key Laboratory of Grassland Agro-ecosystems, Lanzhou University, Lanzhou; 730000, China |
| First Author Affilication | School of Pharmacy |
| Corresponding Author Affilication | School of Pharmacy; School of Life Sciences; Lanzhou University |
| Recommended Citation GB/T 7714 | Zhao, Wen-Bin,An, Jun-Xia,Hu, Yong-Mei,et al. Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Botrytis cinerea Contributes to Disease Control and Fruit Quality Preservation[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(39):12297-12309. |
| APA | Zhao, Wen-Bin.,An, Jun-Xia.,Hu, Yong-Mei.,Li, An-Ping.,Zhang, Shao-Yong.,...&Liu, Ying-Qian.(2022).Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Botrytis cinerea Contributes to Disease Control and Fruit Quality Preservation.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(39),12297-12309. |
| MLA | Zhao, Wen-Bin,et al."Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Botrytis cinerea Contributes to Disease Control and Fruit Quality Preservation".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.39(2022):12297-12309. |
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