|Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system|
|Li, Xinming; Liu, P(刘鹏)|
|Source Publication||Journal of Materials Chemistry B
Impact Factor & Quartile|
|Abstract||Polyprodrugs with drugs as the structural units have been recognized as promising drug self-delivery systems (DSDSs) for tumor chemotherapy, especially ones in which the drug structural units are linked with both pH- and reduction-cleavable conjugations. However, stable DOX derivatives are released after the acid/reduction co-triggered degradation, exhibiting low antitumor efficacy due to their low solubility. Herein, a novel acid/reduction co-triggered degradable amphiphilic copolyprodrug was designed via the facile polycondensation of an acid-labile dimer (D-DOXADH) and disulfide-containing monomer (DNC) with a PEGylated dimer (D-DOXADH-PEG) as an end-capping reagent. The resultant amphiphilic copolyprodrug (PDOXSS-ADH-PEG) with a high DOX content of 61.1% could easily self-assemble into nanoparticles around 154 nm in size, possessing excellent acid/reduction co-triggered DOX release and enhanced inhibition of tumor growth compared to free DOX towards HepG2 cells but showed good cytocompatibility towards L02 cells. © 2022 The Royal Society of Chemistry.|
|Keyword||Controlled drug delivery
Targeted drug delivery
Inhibition of tumor growth
|Publisher||Royal Society of Chemistry
|EI Accession Number||20221511939132
|EI Classification Number||461.2 Biological Materials and Tissue Engineering
; 461.6 Medicine and Pharmacology
; 815.1.1 Organic Polymers
; 951 Materials Science
|Original Document Type||Journal article (JA)
|Corresponding Author||Liu, Peng|
|Affiliation||State Key Laboratory of Applied Organic Chemistry, Lanzhou University, College of Chemistry and Chemical Engineering, Lanzhou; 730000, China|
|First Author Affilication||College of Chemistry and Chemical Engineering
|Corresponding Author Affilication||College of Chemistry and Chemical Engineering
Li, Xinming,Liu, Peng. Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system[J].
Journal of Materials Chemistry B,2022,10(15):2926-2932.
Li, Xinming,&Liu, Peng.(2022).Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system.Journal of Materials Chemistry B,10(15),2926-2932.
Li, Xinming,et al."Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system".Journal of Materials Chemistry B 10.15(2022):2926-2932.
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