Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system

doi:10.1039/d2tb00150k

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	Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system
	Li, Xinming; Liu, P(刘鹏)
	2022-03-04
Source Publication	Journal of Materials Chemistry B Impact Factor & Quartile
ISSN	2050-750X
Volume	10 Issue:15 Pages:2926-2932
Abstract	Polyprodrugs with drugs as the structural units have been recognized as promising drug self-delivery systems (DSDSs) for tumor chemotherapy, especially ones in which the drug structural units are linked with both pH- and reduction-cleavable conjugations. However, stable DOX derivatives are released after the acid/reduction co-triggered degradation, exhibiting low antitumor efficacy due to their low solubility. Herein, a novel acid/reduction co-triggered degradable amphiphilic copolyprodrug was designed via the facile polycondensation of an acid-labile dimer (D-DOXADH) and disulfide-containing monomer (DNC) with a PEGylated dimer (D-DOXADH-PEG) as an end-capping reagent. The resultant amphiphilic copolyprodrug (PDOXSS-ADH-PEG) with a high DOX content of 61.1% could easily self-assemble into nanoparticles around 154 nm in size, possessing excellent acid/reduction co-triggered DOX release and enhanced inhibition of tumor growth compared to free DOX towards HepG2 cells but showed good cytocompatibility towards L02 cells. © 2022 The Royal Society of Chemistry.
Keyword	Controlled drug delivery Tumors Drug products Sulfur compounds Targeted drug delivery Self assembly Chemotherapy % reductions Acid-labile Amphiphilics Anti-tumor efficacy Delivery systems End-capping reagent Inhibition of tumor growth Pegylated Self-assemble Structural unit
Publisher	Royal Society of Chemistry
DOI	10.1039/d2tb00150k
Indexed By	EI
Language	英语
EI Accession Number	20221511939132
EI Keywords	Dimers
EI Classification Number	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 815.1.1 Organic Polymers ; 951 Materials Science
Original Document Type	Journal article (JA)
Citation statistics	Cited Times:4[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	https://ir.lzu.edu.cn/handle/262010/487367
Collection	化学化工学院
Corresponding Author	Liu, Peng
Affiliation	State Key Laboratory of Applied Organic Chemistry, Lanzhou University, College of Chemistry and Chemical Engineering, Lanzhou; 730000, China
First Author Affilication	College of Chemistry and Chemical Engineering
Corresponding Author Affilication	College of Chemistry and Chemical Engineering
Recommended Citation GB/T 7714	Li, Xinming,Liu, Peng. Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system[J]. Journal of Materials Chemistry B,2022,10(15):2926-2932.
APA	Li, Xinming,&Liu, Peng.(2022).Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system.Journal of Materials Chemistry B,10(15),2926-2932.
MLA	Li, Xinming,et al."Synthesis and self-assembly of an acid/reduction co-triggered degradable amphiphilic copolyprodrug as a tumor-selective drug self-delivery system".Journal of Materials Chemistry B 10.15(2022):2926-2932.

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