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Dual-Site Fluorescent Sensor as a Multiple Logic System for Studying the Dichotomous Function of Sulfur Dioxide under Oxidative Stress Induced by Peroxynitrite
Song, Xuerui1; Guo, Yanxuan2; Jing, Chunlin1; Feng, Y(冯燕)1; Cao, Chen1; Kou, Manchang1; Liu, WS(刘伟生)1; Wang, DG(王德贵)2
2022-04-19
Source PublicationANALYTICAL CHEMISTRY   Impact Factor & Quartile
ISSN0003-2700
Volume94Issue:15Pages:5744-5751
AbstractIntracellular reactive oxygen species and reactive sulfur play a vital role in regulating redox homeostasis and maintaining cell functions. Sulfur dioxide (SO2) has emerged as an important gas signal molecule recently, which is not only a potential reducing agent but also a potential inductor of oxidative stress in organisms. Due to high reactivity, peroxynitrite (ONOO-) could act on many biomolecules, such as proteins, lipids, and nucleic acids, and cause irreversible damage, eventually leading to cell apoptosis or necrosis. In order to further illuminate the dichotomous role of SO2under oxidative stress induced by ONOO-, we designed the first dual-site fluorescent sensor (NIR-GYf) for separate or continuous detection of SO2and ONOO-. NIR-GYf was successfully used for cell imaging of endogenous SO2and ONOO-. In addition, western blotting analysis was used to verify the oxidation and antioxidation of SO2and its dichotomous biological influence. Finally, NIR-GYf was integrated with multiple Boolean logic operations to construct an advanced analysis device, thereby realizing the direct analysis of SO2and ONOO-levels. © 2022 American Chemical Society. All rights reserved.
KeywordInfrared devices Cell death Sulfur dioxide Oxidative stress Molecular biology Computer circuits Fluorescence Cell functions Dichotomous function Dual sites Fluorescent sensors Homoeostasis Logic systems Multiple logic Peroxynitrites Reactive oxygen species Stress-induced
PublisherAmerican Chemical Society
DOI10.1021/acs.analchem.1c03792
Indexed ByEI
Language英语
EI Accession Number20221612006644
EI KeywordsNucleic acids
EI Classification Number461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 721.3 Computer Circuits ; 741.1 Light/Optics ; 801.2 Biochemistry ; 804.1 Organic Compounds ; 804.2 Inorganic Compounds
Original Document TypeJournal article (JA)
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/487394
Collection新闻与传播学院
化学化工学院
基础医学院
Corresponding AuthorLiu, Weisheng; Wang, Degui
Affiliation
1.Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Gansu, Lanzhou; 730000, China;
2.School of Basic Medical Sciences, Lanzhou University, Gansu, Lanzhou; 730000, China
First Author AffilicationCollege of Chemistry and Chemical Engineering
Corresponding Author AffilicationCollege of Chemistry and Chemical Engineering;  School of Basic Medical Sciences
Recommended Citation
GB/T 7714
Song, Xuerui,Guo, Yanxuan,Jing, Chunlin,et al. Dual-Site Fluorescent Sensor as a Multiple Logic System for Studying the Dichotomous Function of Sulfur Dioxide under Oxidative Stress Induced by Peroxynitrite[J]. ANALYTICAL CHEMISTRY,2022,94(15):5744-5751.
APA Song, Xuerui.,Guo, Yanxuan.,Jing, Chunlin.,Feng, Yan.,Cao, Chen.,...&Wang, Degui.(2022).Dual-Site Fluorescent Sensor as a Multiple Logic System for Studying the Dichotomous Function of Sulfur Dioxide under Oxidative Stress Induced by Peroxynitrite.ANALYTICAL CHEMISTRY,94(15),5744-5751.
MLA Song, Xuerui,et al."Dual-Site Fluorescent Sensor as a Multiple Logic System for Studying the Dichotomous Function of Sulfur Dioxide under Oxidative Stress Induced by Peroxynitrite".ANALYTICAL CHEMISTRY 94.15(2022):5744-5751.
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