| Construction of Self-Activated Nanoreactors for Cascade Catalytic Anti-Biofilm Therapy Based on H2O2 Self-Generation and Switch-On NO Release | |
Shi, Yuting1; Cao, Yufei1; Cheng, Ju1,2; Yu, Wenwen3; Liu, Mingsheng1; Yin, Juanjuan1; Huang, Congshu1; Liang, Xiaoqin4; Zhou, Haicun3; Liu, Hongbin3; Yang, Zheng1; Fang, Yu1; Wei, H(魏华)1 ; Zhao, GH(赵光辉)1 | |
| 2022-05-13 | |
| Source Publication | ADVANCED FUNCTIONAL MATERIALS Impact Factor & Quartile |
| ISSN | 1616-301X |
| Volume | 32Issue:20 |
| Abstract | The traditional treatment for bacterial infections is the use of antibiotics, but the overuse of antibiotics can lead to the formation of multidrug-resistant bacteria, and eventually lead to the formation of biofilms, which can resist the attack of the host immune system and the penetration of antibiotics in biofilms. Although biofilm-targeted and stimulus-responsive antibiotic delivery nanocarriers are available, the drugs that can be delivered is extremely limited. Therefore, an amphiphilic supramolecule Arg-CD-AcMH is constructed via host–guest interactions between β-CD-terminated arginine (Arg-CD) and ferrocene-terminated acetal-modified maltoheptaose. The amphiphilic supramolecule Arg-CD-AcMH can self-assemble with glucoamylase and glucose oxidase in aqueous solution to form spherical nanoparticles through hydrophilic–hydrophobic and electrostatic interactions. These nanoparticles can respond to the micro-environment in the biofilm and selectively increase the level of H2O2 in the biofilm through the cascading catalytic effect of enzymes based on the self-supply glucose, thus providing conditions for the release of anti-biofilm active drug nitric oxide. © 2022 Wiley-VCH GmbH. |
| Keyword | Glucose oxidase Organometallics Targeted drug delivery Amino acids Antibiotics Iron compounds Nanoparticles Controlled drug delivery Biofilms Glucose Glucose sensors Amphiphilics Antibiofilms Bacterial infections Cascade Multidrug resistants NO release Self-activated Self-generation Supramolecules Switch-on |
| Publisher | John Wiley and Sons Inc |
| DOI | 10.1002/adfm.202111148 |
| Indexed By | EI |
| Language | 英语 |
| EI Accession Number | 20220711647071 |
| EI Keywords | Nitric oxide |
| EI Classification Number | 461.6 Medicine and Pharmacology ; 461.9 Biology ; 462.1 Biomedical Equipment, General ; 462.5 Biomaterials (including synthetics) ; 761 Nanotechnology ; 804.1 Organic Compounds ; 804.2 Inorganic Compounds ; 933 Solid State Physics |
| Original Document Type | Journal article (JA) |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/487438 |
| Collection | 化学化工学院 |
| Corresponding Author | Zhao, Guanghui |
| Affiliation | 1.State Key Laboratory of Applied Organic Chemistry, Institute of Biochemical Engineering & Environmental Technology, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Road, Lanzhou; 730000, China; 2.School of Basic Medical Science, Lanzhou University, 222 Tianshui Road, Lanzhou; 730000, China; 3.The Second Clinical Medical College, Lanzhou University, Lanzhou; 730000, China; 4.Department of Pathology, Gansu Province People's Hospital, Lanzhou; 730000, China |
| First Author Affilication | College of Chemistry and Chemical Engineering |
| Corresponding Author Affilication | College of Chemistry and Chemical Engineering |
| Recommended Citation GB/T 7714 | Shi, Yuting,Cao, Yufei,Cheng, Ju,et al. Construction of Self-Activated Nanoreactors for Cascade Catalytic Anti-Biofilm Therapy Based on H2O2 Self-Generation and Switch-On NO Release[J]. ADVANCED FUNCTIONAL MATERIALS,2022,32(20). |
| APA | Shi, Yuting.,Cao, Yufei.,Cheng, Ju.,Yu, Wenwen.,Liu, Mingsheng.,...&Zhao, Guanghui.(2022).Construction of Self-Activated Nanoreactors for Cascade Catalytic Anti-Biofilm Therapy Based on H2O2 Self-Generation and Switch-On NO Release.ADVANCED FUNCTIONAL MATERIALS,32(20). |
| MLA | Shi, Yuting,et al."Construction of Self-Activated Nanoreactors for Cascade Catalytic Anti-Biofilm Therapy Based on H2O2 Self-Generation and Switch-On NO Release".ADVANCED FUNCTIONAL MATERIALS 32.20(2022). |
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