| Allicin-Inspired Heterocyclic Disulfides as Novel Antimicrobial Agents | |
| Wang, Jing-Ru1; Hu, Yong-Mei1; Zhou, Han1; Li, An-Ping2; Zhang, Shao-Yong3; Luo, Xiong-Fei1; Zhang, Bao-Qi1; An, Jun-Xia1; Zhang, Zhi-Jun1; Liu, Ying-Qian1,3,4 | |
| 2022-09-21 | |
| Source Publication | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Impact Factor & Quartile |
| ISSN | 0021-8561 |
| Volume | 70Issue:37Pages:11782-11791 |
| Abstract | In this work, a series of derivatives with disulfide bonds containing pyridine, pyrimidine, thiophene, thiazole, benzothiazole, and quinoline were designed and synthesized based on the various biological activities of allicin disulfide bond functional groups. The antimicrobial activities of the target compounds were determined, and the structure-activity relationships were discussed. Among them, compound S8 demonstrated the most potent antifungal activity in vitro against Monilinia fructicola (M. fructicola), with an EC50 value of 5.92 mu g/mL. Furthermore, an in vivo bioassay revealed that compound S8 exhibited equivalent curative and higher protective effects as the positive drug thiophanate methyl at a concentration of 200 mu g/mL. The preliminary mechanism experiments showed that compound S8 could inhibit the growth of M. fructicola' s hyphae in a time-and concentration-dependent manner, and compound S8 could induce the shrinkage of hyphae, disrupt the integrity of the plasma membrane, and cause the damage and leakage of cell contents. More than that, compound S5 also demonstrated an excellent antibacterial effect on Xanthomonas oryzae (X. oryzae), with a MIC90 value of 1.56 mu g/mL, which was superior to the positive control, thiodiazole copper. |
| Keyword | disulfide allicin antifungal activity antibacterial activity |
| Publisher | AMER CHEMICAL SOC |
| DOI | 10.1021/acs.jafc.2c03765 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Agriculture ; Chemistry ; Food Science & Technology |
| WOS Subject | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| WOS ID | WOS:000852648200001 |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/488300 |
| Collection | 兰州大学 |
| Affiliation | 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China; 2.Gansu Inst Drug Control, Lanzhou, Peoples R China; 3.Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou 313000, Peoples R China; 4.Lanzhou Univ, State Key Lab Grassland Agroecosystems, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Jing-Ru,Hu, Yong-Mei,Zhou, Han,et al. Allicin-Inspired Heterocyclic Disulfides as Novel Antimicrobial Agents[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(37):11782-11791. |
| APA | Wang, Jing-Ru.,Hu, Yong-Mei.,Zhou, Han.,Li, An-Ping.,Zhang, Shao-Yong.,...&Liu, Ying-Qian.(2022).Allicin-Inspired Heterocyclic Disulfides as Novel Antimicrobial Agents.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(37),11782-11791. |
| MLA | Wang, Jing-Ru,et al."Allicin-Inspired Heterocyclic Disulfides as Novel Antimicrobial Agents".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.37(2022):11782-11791. |
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