兰州大学机构库
Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Botrytis cinerea Contributes to Disease Control and Fruit Quality Preservation
Zhao, Wen-Bin1; An, Jun-Xia1; Hu, Yong-Mei1; Li, An-Ping1; Zhang, Shao-Yong2; Zhang, Bao-Qi1; Zhang, Zhi-Jun1; Luo, Xiong-Fei1; Bian, Qiang4; Ma, Yue1; Ding, Yan-Yan1; Wang, Rui3; Liu, Ying-Qian1,2,5
2022-09-01
Online publication date2022-09
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   Impact Factor & Quartile
ISSN0021-8561
EISSN1520-5118
Volume70Issue:39Pages:12297-12309
page numbers13
AbstractThe inhibitory effect of tavaborole on the invasion of Botrytis cinerea in grapes and tomatoes, as well as the potential mechanism involved, was discovered in this study. Our findings showed that tavaborole inhibited Bonytis cinerea spore germination and mycelial expansion in vitro and that the control efficiency in vivo on fruit decay was dose-dependent, which was effective in reducing disease severity and maintaining the organoleptic quality of the fruit, such as reducing weight loss and retaining fruit hardness and titratable acid contents during storage. Furthermore, the precise mechanism of action was investigated further. Propidium iodide staining revealed that Botrvtis cinerea treated with tavaborole lost membrane integrity. For further validation, cytoplasmic malondialdehyde accumulation and leakage of cytoplasmic constituents were determined. Notably, the inhibitory effect was also dependent on inhibiting the activities of aminoacyl-tRNA synthetases involved in the aminoacyl-tRNA biosynthesis pathway in Botrytis cinerea. The above findings concluded that tavaborole was effective against Bonytis cinerea infection in postharvest fruit, and a related mechanism was also discussed, which may provide references for the drug repurposing of tavaborole as a postharvest fungicide.
KeywordBotrytis cinerea tavaborole membrane integrity aminoacyl-tRNA synthetases
PublisherAMER CHEMICAL SOC
DOI10.1021/acs.jafc.2c03441
Indexed BySCIE
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000869782100001
Original Document TypeArticle ; Early Access
PMID 36149871
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/488680
Collection兰州大学
Corresponding AuthorBian, Qiang; Liu, Ying-Qian
Affiliation
1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China;
2.Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou 313000, Peoples R China;
3.Weifang Univ, Key Lab Biochem & Mol Biol Univ Shandong Prov, Weifang 261061, Peoples R China;
4.Nankai Univ, Coll Chem, Natl Pesticide Engn Res Ctr Tianjin, Tianjin 300071, Peoples R China;
5.Lanzhou Univ, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Wen-Bin,An, Jun-Xia,Hu, Yong-Mei,et al. Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Botrytis cinerea Contributes to Disease Control and Fruit Quality Preservation[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(39):12297-12309.
APA Zhao, Wen-Bin.,An, Jun-Xia.,Hu, Yong-Mei.,Li, An-Ping.,Zhang, Shao-Yong.,...&Liu, Ying-Qian.(2022).Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Botrytis cinerea Contributes to Disease Control and Fruit Quality Preservation.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(39),12297-12309.
MLA Zhao, Wen-Bin,et al."Tavaborole-Induced Inhibition of the Aminoacyl-tRNA Biosynthesis Pathway against Botrytis cinerea Contributes to Disease Control and Fruit Quality Preservation".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.39(2022):12297-12309.
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