| cRGD-targeted gold-based nanoparticles overcome EGFR-TKI resistance of NSCLC via low-temperature photothermal therapy combined with sonodynamic therapy | |
| Lv, Wenhao1,2; Wu, Hao1,2; Zhang, Yao1; Li, Hui1; Shu, Hong1; Su, Chunhong1; Zhu, Yangyang1,2; Wang, Ting1,2; Nie, Fang1,2 | |
| 2023 | |
| Source Publication | BIOMATERIALS SCIENCE
 |
| ISSN | 2047-4830 |
| Abstract | Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is a first-line targeted drug for the treatment of advanced non-small cell lung cancer (NSCLC) in clinical practice, but EGFR-TKI-acquired resistance limits its therapeutic effect. To address this challenge, a novel multifunctional gold-based targeted nanoparticle-based drug delivery system is fabricated. The gold-based nanoparticle is loaded with the EGFR-TKI (gefitinib) and IR780, and the surface-modified gold nanoshell layer has a photothermal effect for thermally triggered drug release. Finally, the unique binding of cyclic arginine-glycine-aspartic acid (cRGD) to the alpha(v)beta(3) receptor ensured that the nanoparticle (cRGD-GIPG) targeted transport into drug-resistant NSCLC cells was functional. Due to the sonodynamic properties of IR780, ultrasound (US) irradiation promoted reactive oxygen species (ROS) generation, while low-temperature photothermal therapy (PTT) not only promoted the release of drug, but also further enhanced the cytotoxic effects of ROS. In turn, it blocked the activation of TGF-beta/PDLIM5/SMAD resistance pathway and induced apoptosis of drug-resistant cells through mitochondrial apoptosis, enabling the treatment of EGFR-TKI-resistant NSCLC. The low-temperature PTT combined with sonodynamic therapy (SDT) by cRGD-GIPG thus shows potent anticancer activity against EGFR-TKI-resistant NSCLC cells in vitro and in vivo. The present work provides a valuable strategy for highly targeted and EGFR-TKI-resistant reversal therapy in NSCLC. |
| Publisher | ROYAL SOC CHEMISTRY |
| DOI | 10.1039/d2bm01825j |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Biomaterials |
| WOS ID | WOS:000909713700001 |
| Original Document Type | Article ; Early Access |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/492540 |
| Collection | 兰州大学 |
| Affiliation | 1.Lanzhou Univ, Hosp 2, Ultrasound Med Ctr, Lanzhou 730000, Peoples R China; 2.Gansu Prov Clin Res Ctr Ultrasonog, Lanzhou 730000, Peoples R China |
| First Author Affilication | Second Clinical School |
| Recommended Citation GB/T 7714 | Lv, Wenhao,Wu, Hao,Zhang, Yao,et al. cRGD-targeted gold-based nanoparticles overcome EGFR-TKI resistance of NSCLC via low-temperature photothermal therapy combined with sonodynamic therapy[J]. BIOMATERIALS SCIENCE,2023. |
| APA | Lv, Wenhao.,Wu, Hao.,Zhang, Yao.,Li, Hui.,Shu, Hong.,...&Nie, Fang.(2023).cRGD-targeted gold-based nanoparticles overcome EGFR-TKI resistance of NSCLC via low-temperature photothermal therapy combined with sonodynamic therapy.BIOMATERIALS SCIENCE. |
| MLA | Lv, Wenhao,et al."cRGD-targeted gold-based nanoparticles overcome EGFR-TKI resistance of NSCLC via low-temperature photothermal therapy combined with sonodynamic therapy".BIOMATERIALS SCIENCE (2023). |
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