| Investigation of the mechanism of tanshinone IIA to improve cognitive function via synaptic plasticity in epileptic rats | |
| Jia, Chen1; Zhang, Rui2; Wei, Liming1; Xie, Jiao3; Zhou, Suqin1; Yin, Wen1; Hua, Xi4; Xiao, Nan4; Ma, Meile4; Jiao, Haisheng1,5 | |
| 2023-12-31 | |
| Source Publication | PHARMACEUTICAL BIOLOGY Impact Factor & Quartile |
| ISSN | 1388-0209 |
| EISSN | 1744-5116 |
| Volume | 61Issue:1Pages:100-110 |
| page numbers | 11 |
| Abstract | Context Tanshinone IIA is an extract of Salvia miltiorrhiza Bunge (Labiatae) used to treat cardiovascular disorders. It shows potential anticonvulsant and cognition-protective properties. Objective We investigated the mechanism of tanshinone IIA on antiepileptic and cognition-protective effects in the model of epileptic rats. Materials and methods Lithium chloride (LiCl)-pilocarpine-induced epileptic Wistar rats were randomly assigned to the following groups (n = 12): control (blank), model, sodium valproate (VPA, 189 mg/kg/d, positive control), tanshinone IIA low dose (TS IIA-L, 10 mg/kg/d), medium dose (TS IIA-M, 20 mg/kg/d) and high dose (TS IIA-H, 30 mg/kg/d). Then, epileptic behavioural observations, Morris water maze test, Timm staining, transmission electron microscopy, immunofluorescence staining, western blotting and RT-qPCR were measured. Results Compared with the model group, tanshinone IIA reduced the frequency and severity of seizures, improved cognitive impairment, and inhibited hippocampal mossy fibre sprouting score (TS IIA-M 1.50 +/- 0.22, TS IIA-H 1.17 +/- 0.31 vs. model 2.83 +/- 0.31), as well as improved the ultrastructural disorder. Tanshinone IIA increased levels of synapse-associated proteins synaptophysin (SYN) and postsynaptic dense substance 95 (PSD-95) (SYN: TS IIA 28.82 +/- 2.51, 33.18 +/- 2.89, 37.29 +/- 1.69 vs. model 20.23 +/- 3.96; PSD-95: TS IIA 23.10 +/- 0.91, 26.82 +/- 1.41, 27.00 +/- 0.80 vs. model 18.28 +/- 1.01). Discussion and conclusions Tanshinone IIA shows antiepileptic and cognitive function-improving effects, primarily via regulating synaptic plasticity. This research generates a theoretical foundation for future research on potential clinical applications for tanshinone IIA. |
| Keyword | Cognitive impairment epilepsy SYN PSD-95 mossy fibre sprouting |
| Publisher | TAYLOR & FRANCIS LTD |
| DOI | 10.1080/13880209.2022.2157843 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy |
| WOS Subject | Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy |
| WOS ID | WOS:000900831900001 |
| Original Document Type | Article |
| PMID | 36548216 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/492647 |
| Collection | 兰州大学 |
| Corresponding Author | Jiao, Haisheng |
| Affiliation | 1.Lanzhou Univ, Dept Pharm, Hosp 2, Lanzhou, Peoples R China; 2.Gansu Prov Matern & Child Care Hosp, Dept Pharm, Lanzhou, Peoples R China; 3.Xi An Jiao Tong Univ, Dept Pharm, Affiliated Hosp 2, Xian, Peoples R China; 4.Lanzhou Univ, Coll Pharm, Lanzhou, Peoples R China; 5.Lanzhou Univ, Dept Pharm, Hosp 2, Lanzhou 730030, Peoples R China |
| Recommended Citation GB/T 7714 | Jia, Chen,Zhang, Rui,Wei, Liming,et al. Investigation of the mechanism of tanshinone IIA to improve cognitive function via synaptic plasticity in epileptic rats[J]. PHARMACEUTICAL BIOLOGY,2023,61(1):100-110. |
| APA | Jia, Chen.,Zhang, Rui.,Wei, Liming.,Xie, Jiao.,Zhou, Suqin.,...&Jiao, Haisheng.(2023).Investigation of the mechanism of tanshinone IIA to improve cognitive function via synaptic plasticity in epileptic rats.PHARMACEUTICAL BIOLOGY,61(1),100-110. |
| MLA | Jia, Chen,et al."Investigation of the mechanism of tanshinone IIA to improve cognitive function via synaptic plasticity in epileptic rats".PHARMACEUTICAL BIOLOGY 61.1(2023):100-110. |
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