| Significance of NatB-mediated N-terminal acetylation of auxin biosynthetic enzymes in maintaining auxin homeostasis in Arabidopsis thaliana | |
| Liu, Hai-Qing1; Pu, Zuo-Xian1,2; Di, Dong-Wei1,3; Zou, Ya-Jie1,2; Guo, Yu-Man1,2; Wang, Jun-Li1,2; Zhang, Li1,4; Tian, Peng1,2; Fei, Qiong-Hui1,2; Li, Xiao-Feng1,2; Khaskheli, Allah Jurio1,2; Wu, Lei1,2; Guo, Guang-Qin1,2 | |
| 2022-12-22 | |
| Source Publication | COMMUNICATIONS BIOLOGY Impact Factor & Quartile |
| Volume | 5Issue:1 |
| page numbers | 8 |
| Abstract | The auxin IAA (Indole-3-acetic acid) plays key roles in regulating plant growth and development, which depends on an intricate homeostasis that is determined by the balance between its biosynthesis, metabolism and transport. YUC flavin monooxygenases catalyze the rate-limiting step of auxin biosynthesis via IPyA (indole pyruvic acid) and are critical targets in regulating auxin homeostasis. Despite of numerous reports on the transcriptional regulation of YUC genes, little is known about those at the post-translational protein level. Here, we show that loss of function of CKRC3/TCU2, the auxiliary subunit (Naa25) of Arabidopsis NatB, and/or of its catalytic subunit (Naa20), NBC, led to auxin-deficiency in plants. Experimental evidences show that CKRC3/TCU2 can interact with NBC to form a NatB complex, catalyzing the N-terminal acetylation (NTA) of YUC proteins for their intracellular stability to maintain normal auxin homeostasis in plants. Hence, our findings provide significantly new insight into the link between protein NTA and auxin biosynthesis in plants. |
| Publisher | NATURE PORTFOLIO |
| DOI | 10.1038/s42003-022-04313-9 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics |
| WOS Subject | Biology ; Multidisciplinary Sciences |
| WOS ID | WOS:000903280800007 |
| Original Document Type | Article |
| PMID | 36550195 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/492776 |
| Collection | 兰州大学 |
| Corresponding Author | Wu, Lei; Guo, Guang-Qin |
| Affiliation | 1.Lanzhou Univ, Sch Life Sci, MOE Key Lab Cell Act & Stress Adaptat, Lanzhou 730000, Peoples R China; 2.Lanzhou Univ, Sch Life Sci, Gansu Prov Key Lab Gene Editing Breeding, Lanzhou 730000, Peoples R China; 3.Inst Soil Sci, Chinese Acad Sci, Nanjing 210008, Peoples R China; 4.Fujian Agr & Forestry Univ, Coll Life Sci, Basic Forestry & Prote Res Ctr, Fuzhou 350002, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Hai-Qing,Pu, Zuo-Xian,Di, Dong-Wei,et al. Significance of NatB-mediated N-terminal acetylation of auxin biosynthetic enzymes in maintaining auxin homeostasis in Arabidopsis thaliana[J]. COMMUNICATIONS BIOLOGY,2022,5(1). |
| APA | Liu, Hai-Qing.,Pu, Zuo-Xian.,Di, Dong-Wei.,Zou, Ya-Jie.,Guo, Yu-Man.,...&Guo, Guang-Qin.(2022).Significance of NatB-mediated N-terminal acetylation of auxin biosynthetic enzymes in maintaining auxin homeostasis in Arabidopsis thaliana.COMMUNICATIONS BIOLOGY,5(1). |
| MLA | Liu, Hai-Qing,et al."Significance of NatB-mediated N-terminal acetylation of auxin biosynthetic enzymes in maintaining auxin homeostasis in Arabidopsis thaliana".COMMUNICATIONS BIOLOGY 5.1(2022). |
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