兰州大学机构库 >基础医学院
An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects
Zhou, Jingjing1,2; Cha, Ruitao3; Wu, Zhiyu4; Zhang, Chunliang3; He, Yuhang1; Zhang, Hanru1; Liu, Kexin1; Fareed, Muhammad Subaan1; Wang, Zhaopeng1; Yang, Changyan1; Zhang, Yifan5; Yan, WJ(阎文锦)1; Wang, KR(王凯荣)1,2
2023-04-01
Online publication date2023-03
Source PublicationNano Today   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN1748-0132
Volume49
page numbers16
AbstractWounds, especially refractory wounds infected by drug-resistant bacteria, threaten patients’ health seriously. The development of wound dressings is urgently needed to address this problem. Herein, we report a peptide hydrogel formed by natural antimicrobial peptide Jelleine-1 and its potential use for MRSA-infected wounds. We studied the formation of Jelleine-1 hydrogel, its antimicrobial activity, biodegradability, biocompatibility, and wound healing effects. Our results showed that Jelleine-1 hydrogel was formed by the physical crosslinking of self-assembled Jelleine-1 nanofibers in PBS without any other chemical crosslinkers. It exhibited broad spectrum of antimicrobial activity and excellent biocompatibility. Notably, the hydrogel showed great potential in promoting wound healing in a mouse model with MRSA-infected burn wound. Our study would provide an inherent antimicrobial hydrogel dressing without loading antibiotics for wounds infected by drug-resistant bacteria, broaden the application of antimicrobial peptides, and pave an alternative strategy for the design of antimicrobial hydrogel. © 2023 Elsevier Ltd
KeywordBacteria Biodegradability Crosslinking Hydrogels Peptides Self assembly Self-healing materials Anti-microbial activity Antimicrobial peptide Drug-resistant bacteria Injectables Jelleine-1 Natural peptide Patient health Peptide hydrogels Promoting effect Wound healing Peptide hydrogel Biocompatibility Self-assembly
PublisherElsevier B.V.
DOI10.1016/j.nantod.2023.101801
Indexed ByEI ; SCIE
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000995564800001
EI Accession Number20231013666395
EI KeywordsBiocompatibility
EI Classification Number415 Metals, Plastics, Wood and Other Structural Materials ; 461.9 Biology ; 461.9.1 Immunology ; 801.2 Biochemistry ; 801.3 Colloid Chemistry ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 951 Materials Science
Original Document TypeJournal article (JA) ; Article
ESI Hot Paper2024-03
ESI Hicited Paper2024-03
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/498452
Collection基础医学院
Corresponding AuthorCha, Ruitao; Wang, Kairong
Affiliation
1.Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Research Unit of Peptide Science, Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, West Donggang Road 199, Lanzhou; 730000, China;
2.State Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Lanzhou University, Lanzhou; 730000, China;
3.CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing; 100190, China;
4.The First School of Clinical Medicine, Lanzhou University, West Donggang Road 199, Lanzhou; 730000, China;
5.School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta; GA; 30332, United States
First Author AffilicationSchool of Basic Medical Sciences;  Lanzhou University
Corresponding Author AffilicationSchool of Basic Medical Sciences;  Lanzhou University
First Signature AffilicationSchool of Basic Medical Sciences
Recommended Citation
GB/T 7714
Zhou, Jingjing,Cha, Ruitao,Wu, Zhiyu,et al. An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects[J]. Nano Today,2023,49.
APA Zhou, Jingjing.,Cha, Ruitao.,Wu, Zhiyu.,Zhang, Chunliang.,He, Yuhang.,...&Wang, Kairong.(2023).An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects.Nano Today,49.
MLA Zhou, Jingjing,et al."An injectable, natural peptide hydrogel with potent antimicrobial activity and excellent wound healing-promoting effects".Nano Today 49(2023).
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