| Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi | |
Li, Hai-Xin1; Luo, Xiong-Fei1; Deng, Peng1; Zhang, Shao-Yong2; Zhou, Han1; Ding, Yan Yan1; Wang, Yi-Rong1; Liu, YQ(刘映前)1,2,3 ; Zhang, ZJ(张智军)1 | |
| 2023-02-08 | |
| Source Publication | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Impact Factor & Quartile |
| ISSN | 0021-8561 |
| Volume | 71Issue:5Pages:2301-2312 |
| Abstract | A series of quinoline derivatives were designed and synthesized by the structural simplification of cryptolepine and evaluated for their fungicidal activity against six phytopathogenic fungi. Most of these compounds exhibited remarkable activities against Botrytis cinereain vitro. Among them, compounds A18 and L01 showed superior antifungal activity. Significantly, compared to cryptolepine, compound A18 exhibited broad-spectrum inhibitory activities against B. cinerea, Sclerotinia sclerotiorum, Rhizoctonia solani, Phytophthora capsica, Magnaporthe oryzae, and Fusarium graminearum with the respective EC50 values of 0.249, 1.569, 3.915, 0.505, 0.246, and 4.999 μg/mL. Compound L01 displayed the best antifungal activity against B. cinerea with an EC50 value of 0.156 μg/mL. Preliminary mechanistic studies showed that compound A18 could inhibit spore germination, affect the permeability of the cell membrane, increase the content of reactive oxygen species, and affect the morphology of hyphae and cells. Moreover, compound A18 showed excellent in vivo protective effect against B. cinerea, which was more potent than pyrimethanil and equitant to cryptolepine. These results evidenced that compound A18 displayed superior fungicidal activities and could be a potential fungicidal candidate against plant fungal diseases. © 2023 American Chemical Society. |
| Keyword | Fungi Fungicides Antifungal activities Antifungals Botrytis cinerea Cryptolepine Fungicidal activity Phytopathogenic fungi Quinoline derivative Structural simplification Structure-activity relationships Synthesised |
| Publisher | American Chemical Society |
| DOI | 10.1021/acs.jafc.2c07575 |
| Indexed By | EI |
| Language | 英语 |
| EI Accession Number | 20230713586157 |
| EI Keywords | Cytology |
| EI Classification Number | 461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 804.1 Organic Compounds |
| Original Document Type | Journal article (JA) |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/498472 |
| Collection | 药学院 |
| Corresponding Author | Liu, Ying-Qian; Zhang, Zhi-Jun |
| Affiliation | 1.School of Pharmacy, Lanzhou University, Lanzhou; 730000, China; 2.Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou; 313000, China; 3.State Key Laboratory of Grassland Agro-ecosystems, Lanzhou University, Lanzhou; 730000, China |
| First Author Affilication | School of Pharmacy |
| Corresponding Author Affilication | School of Pharmacy; Lanzhou University |
| Recommended Citation GB/T 7714 | Li, Hai-Xin,Luo, Xiong-Fei,Deng, Peng,et al. Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(5):2301-2312. |
| APA | Li, Hai-Xin.,Luo, Xiong-Fei.,Deng, Peng.,Zhang, Shao-Yong.,Zhou, Han.,...&Zhang, Zhi-Jun.(2023).Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(5),2301-2312. |
| MLA | Li, Hai-Xin,et al."Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.5(2023):2301-2312. |
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