兰州大学机构库 >药学院
Potent intrinsic bactericidal activity of novel copper telluride nano-grape clusters with facile preparation
Zhou, Yanwen1,2; Lei, Haozhuo2; Wang, Meng2; Shi, YB(史彦斌)2; Wang, Zhaohui1,2
2023-01-03
Source PublicationBiomaterials Science   Impact Factor & Quartile
ISSN2047-4830
Volume11Issue:5Pages:1828-1839
AbstractBactericidal nanomedicines often suffer from a complicated design and insufficient intrinsic inhibitory efficacy. Herein, novel anti-bacterial copper telluride (CuTe) nano-clusters are reported, featuring superior bactericidal efficiency, facile preparation, and unique mechanism. These nanoparticles, well dispersable in water, resembled grape clusters with rough surfaces. The CuTe nano-grape clusters exhibited ultra-high sterilization efficacy at ultra-low concentration, particularly for Gram-negative bacteria, and were more potent than conventional anti-microbial nanoparticles. Also, the grape clusters effectively inhibited the bacterial biofilm development. Further investigation revealed the synergized mechanisms of reactive oxygen species (ROS) generation and glutathione (GSH) depletion. Interestingly, electron microscopy revealed that the grape clusters served as bacterial hunters by tightly adhering to bacterial surfaces. The bacteria subsequently suffered from the leakage of various intracellular components including nucleic acid, proteins, and potassium. Most encouragingly, CuTe drastically reduced bacterial number in a mouse model with lethal intraperitoneal infection and increased the mouse survival rate to 90%. This finding could inspire the development of highly potent bactericidal inorganic formulations with simplified structure, multiple antibacterial mechanisms, and promising application potential. © 2023 The Royal Society of Chemistry.
KeywordBacteria Copper compounds Nanoclusters Nucleic acids Anti-bacterial Anti-microbial Bacterial biofilm Bactericidal activity Facile preparation Gram-negative bacteria Nano clusters Rough surfaces Ultra low concentration Ultra-high
PublisherRoyal Society of Chemistry
DOI10.1039/d2bm01617f
Indexed ByEI
Language英语
EI Accession Number20230513461320
EI KeywordsNanoparticles
EI Classification Number461.2 Biological Materials and Tissue Engineering ; 761 Nanotechnology ; 801.2 Biochemistry ; 804.1 Organic Compounds ; 933 Solid State Physics
Original Document TypeJournal article (JA)
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/498613
Collection药学院
Corresponding AuthorShi, Yanbin; Wang, Zhaohui
Affiliation
1.Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou; 570228, China;
2.School of Pharmacy, Lanzhou University, Lanzhou; 730000, China
First Author AffilicationSchool of Pharmacy
Corresponding Author AffilicationSchool of Pharmacy
Recommended Citation
GB/T 7714
Zhou, Yanwen,Lei, Haozhuo,Wang, Meng,et al. Potent intrinsic bactericidal activity of novel copper telluride nano-grape clusters with facile preparation[J]. Biomaterials Science,2023,11(5):1828-1839.
APA Zhou, Yanwen,Lei, Haozhuo,Wang, Meng,Shi, Yanbin,&Wang, Zhaohui.(2023).Potent intrinsic bactericidal activity of novel copper telluride nano-grape clusters with facile preparation.Biomaterials Science,11(5),1828-1839.
MLA Zhou, Yanwen,et al."Potent intrinsic bactericidal activity of novel copper telluride nano-grape clusters with facile preparation".Biomaterials Science 11.5(2023):1828-1839.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Zhou, Yanwen]'s Articles
[Lei, Haozhuo]'s Articles
[Wang, Meng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, Yanwen]'s Articles
[Lei, Haozhuo]'s Articles
[Wang, Meng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, Yanwen]'s Articles
[Lei, Haozhuo]'s Articles
[Wang, Meng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.