兰州大学机构库 >材料与能源学院
A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing
Li, Chunyang1; He, Xiaojun2; Li, Qingfeng3; Lv, Mingzhi1; Shen, Jianliang2,4; Jin, Lin3; He, Deyan1
2023-12-01
Source PublicationNPG Asia Materials   Impact Factor & Quartile
ISSN1884-4049
Volume15Issue:1
page numbers10
AbstractDuring wound healing, oxygen availability and the anti-inflammatory microenvironment play an important role in the formation of new tissue. However, providing continuous and controllable oxygen around the injured tissue while inhibiting inflammation and realizing the synergistic effect of oxygen supply and anti-inflammation is still a major problem affecting the regeneration and repair of wound tissue. Inspired by skin wound pathology and the inflammatory microenvironment, a photothermal response-assisted strategy was developed in this study. We prepared a composite hydrogel system of polydopamine-hyaluronic acid (PDA-HA) hydrogel-loaded calcium peroxide-indocyanine green combined with lauric acid and manganese dioxide (CaO2-ICG@LA@MnO2) nanoparticles that showed excellent photothermal performance under near-infrared (NIR) irradiation and realized the on-off release of oxygen and reactive oxygen species (ROS). Controllable and sustainable oxygen release can promote the regeneration and repair of damaged tissue, and the generated ROS can effectively inhibit the outbreak of inflammation at the initial stage of wound healing. We believe that the system we have developed can be used in a new approach for treating chronic wounds. © 2023, The Author(s).
KeywordCalcium compounds Hyaluronic acid Hydrogels Infrared devices Manganese oxide Oxygen supply Pathology Tissue regeneration Anti-inflammation Anti-inflammatories Effect of oxygen Microenvironments Oxygen release Photothermal response Reactive oxygen species Synergistic effect Wound healing Wound tissue
PublisherNature Research
DOI10.1038/s41427-022-00456-7
Indexed ByEI ; SCIE
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000918377000002
EI Accession Number20230313406294
EI KeywordsTissue
EI Classification Number461.1 Biomedical Engineering ; 461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 801.3 Colloid Chemistry ; 804 Chemical Products Generally ; 804.1 Organic Compounds
Original Document TypeJournal article (JA) ; Article
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/498825
Collection材料与能源学院
Corresponding AuthorJin, Lin; He, Deyan
Affiliation
1.School of Materials & Energy, Lanzhou University, Lanzhou; 730000, China;
2.School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou; 325035, China;
3.Henan International Joint Laboratory of Biomedical Nanomaterials, Zhoukou Normal University, Zhoukou; 466001, China;
4.Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou; 325000, China
First Author AffilicationLanzhou University
Corresponding Author AffilicationLanzhou University
First Signature AffilicationLanzhou University
Recommended Citation
GB/T 7714
Li, Chunyang,He, Xiaojun,Li, Qingfeng,et al. A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing[J]. NPG Asia Materials,2023,15(1).
APA Li, Chunyang.,He, Xiaojun.,Li, Qingfeng.,Lv, Mingzhi.,Shen, Jianliang.,...&He, Deyan.(2023).A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing.NPG Asia Materials,15(1).
MLA Li, Chunyang,et al."A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing".NPG Asia Materials 15.1(2023).
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